Polymorphism and Solubility of Nateglinide

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (24): 2817-2820. Previous Articles Next Articles

那格列奈的多晶型与溶解度

李钢*^{,1, 徐群为², 李瑞², 程永科¹, 黄长高¹}

(¹南京师范大学分析测试中心南京 210097)
(²南京医科大学药学院南京 210009)

投稿日期:2007-03-28 修回日期:2007-07-18 发布日期:2007-12-28
通讯作者: 李钢

Polymorphism and Solubility of Nateglinide

LI Gang*^{,1; XU Qun-Wei²; LI Rui²; CHENG Yong-Ke¹; HUANG Chang-Gao¹}

(¹ Testing & Analysis Center, Nanjing Normal University, Nanjing 210097)
(² College of the Medicine, Nanjing Medicine University, Nanjing 210009)

Received:2007-03-28 Revised:2007-07-18 Published:2007-12-28
Contact: LI Gang

Abstract

The solubility values of three forms of nateglinide have been measured at different temperatures, and their enthalpies have been calculated. The results indicated that the solubility values of both S-form and H-form are large than that of B-form clearly. Moreover, a new X2-form of nateglinide was found and its amorphous form was prepared.

Key words: nateglinide, polymorphism, solubility, diabetes, X-ray powder diffraction

Cite this article

LI Gang*^,1; XU Qun-Wei²; LI Rui²; CHENG Yong-Ke; HUANG Chang-Gao¹. Polymorphism and Solubility of Nateglinide[J]. Acta Chimica Sinica, 2007, 65(24): 2817-2820.

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那格列奈的多晶型与溶解度

Polymorphism and Solubility of Nateglinide

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