Studies on structures and synthesis of arteannuin and related compound XIX. Selective protection of 1,6-aldehyde-ketone in 2-(3'-oxobutyl) cyclohexanecarboxaldehyde

Acta Chimica Sinica ›› 1987, Vol. 45 ›› Issue (2): 150-153. Previous Articles Next Articles

Original Articles

青蒿素及其一类物的结构和合成XIX: 2-(3'-氧代丁基)环己基甲醛中1,6-醛酮的选择性保护

朱杰;许杏祥;周维善

中国科学院上海有机化学研究所

发布日期:1987-02-15

Studies on structures and synthesis of arteannuin and related compound XIX. Selective protection of 1,6-aldehyde-ketone in 2-(3'-oxobutyl) cyclohexanecarboxaldehyde

ZHU JIE;XU XINGXIANG;ZHOU WEISHAN

Published:1987-02-15

Abstract

Treating cyclohexanecarboxaldehyde I (R1R2 = R3R4 = O) with MeOH/p-toluenesulfonic acid or CH2(CH2SH)2/BF3譋t2O gave I (R1R2 = O, R3 = R4 = MeO) or I (R1R2 = CH2(CH2S)2, R3R4 = O), resp., both of which could be easily converted to the key intermediate II for the total synthesis of arteannuin.

Key words: MERCAPTAN, INFRARED SPECTROPHOTOMETRY, CYCLOHEXANE P, FORMYL GROUP, PROTON MAGNETIC RESONANCE SPECTROMETRY, ARTEANNUIN, STERIC EFFECT, PROPANE P, KETONE P, SELECTIVE PROTECTION

CLC Number:

O629

Cite this article

ZHU JIE;XU XINGXIANG;ZHOU WEISHAN. Studies on structures and synthesis of arteannuin and related compound XIX. Selective protection of 1,6-aldehyde-ketone in 2-(3'-oxobutyl) cyclohexanecarboxaldehyde[J]. Acta Chimica Sinica, 1987, 45(2): 150-153.

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青蒿素及其一类物的结构和合成XIX: 2-(3'-氧代丁基)环己基甲醛中1,6-醛酮的选择性保护

Studies on structures and synthesis of arteannuin and related compound XIX. Selective protection of 1,6-aldehyde-ketone in 2-(3'-oxobutyl) cyclohexanecarboxaldehyde

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