We have investigated the transport of rare earth ions transporting across the membrane of human peripheral blood lymphocytes (HPBL) by monitoring the fluorescence of HPBL loaded with Fura-2. through unicellular and multicellular aspects we study the behaviors of transporting across the membrane of HPBL about La^3^+, Dy^3^+. In similar physiological conditions, when we activate the calcium channel of HPBL by mitogen: PHA and ConA, the lanthanum ions (0.01 mmol·L^-^1, 0.1 mmol·L^-^1, 1 mmol·L^-^1) cannot pass the membrane through calcium ion entry; And when calcium entry blockers (CEBS) for example Verapamil and Nifedipine block the calcium channel, the lanthanum ions cannot enter across the membrane through other entries, either. It seems to us that the trace lanthanum cannot pass the membrane in above conditions. And we find the lanthanum cannot effect the extracelluar calcium influx across the plasma membrane through calcium entry.

Key words: CALCIUM CHANNELS, RARE EARTH, FLUORESCENCE PROBE, LYMPHOCYTES, DYSPROSIUM ION, LANTHANUM ION