Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (11): 1177-1184.DOI: 10.6023/A20060252 Previous Articles     Next Articles



贾伊祎, 王文杰, 梁玲, 袁荃   

  1. 湖南大学 化学化工学院 化学生物学与纳米医学研究所 长沙 410082
  • 投稿日期:2020-06-19 发布日期:2020-07-28
  • 通讯作者: 袁荃
  • 作者简介:贾伊祎,2018年于华中农业大学理学院获得学士学位,同年加入湖南大学化学化工学院攻读硕士学位,主要研究兴趣为金属框架化合物在生物医学中的应用;王文杰,2018年于华北电力大学(保定)环境科学与工程学院获得学士学位,同年加入湖南大学化学化工学院攻读硕士学位,主要研究兴趣为无机纳米材料在生物医学中的应用.;袁荃,教授,2004年于武汉大学获学士学位,2009年于北京大学获博士学位,2009年至2012年在佛罗里达大学谭蔚泓课题组进行博士后研究.袁荃教授目前在湖南大学化学化工学院进行研究工作,主要研究兴趣包括功能纳米材料的可控合成及其在生物医学中的应用.
  • 基金资助:

Bioassay Applications of Aptamer-Functionalized Rare Earth Nanomaterials

Jia Yiyi, Wang Wenjie, Liang Ling, Yuan Quan   

  1. Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
  • Received:2020-06-19 Published:2020-07-28
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21904037), Natural Science Foundation of Hunan Province, China (Nos. 2020JJ4173, 2020JJ5038) and Changsha Municipal Science and Technology Projects, China (No. Kq1901030).

The levels of some biomolecules and ions in the body are usually related to the structural and functional changes of cells, tissues, organs, etc., which directly affect the prevention, diagnosis, and treatment of diseases. Therefore, in vivo bioassays of these substances are of great significance in medical and healthcare fields. The nano fluorescent probes consisted of rare earth nano materials have advantages of high sensitivity, simplicity, efficiency, and strong anti-interference ability, thus showing great potential in bioassays. The functionalization of aptamers on rare earth nanomaterials can further provide better specific recognition ability and biocompatibility for nano fluorescent probes, thereby enhancing their bioassays ability in complex samples. In this paper, the research progress of aptamer-functionalized rare earth nanomaterials as nano fluorescent probes in the field of bioassays is reviewed, and the main types, properties, detection mechanisms and detection substances are briefly introduced.

Key words: biomolecule, bioassay, fluorescent probe, nanomaterial, rare earth, aptamer