High dispersion Co3O4 nano-particles supported on hollow mesoporous silica spheres (HMSS) were prepared by a novel two-solvent method. The supported nano-particles had been characterized and its catalytic performance had been evaluated. The Co3O4 single clusters were 100～200 nm and dispersed equably in the pore channels. HRTEM and TEM results showed that these single clusters were composed by 10～15 nm mono-dispersed Co3O4 nano-particles, and these Co3O4 nano-particles were loaded in the pore channels of the HMMS and were divided by the pore walls with each other. XRD and Raman spectra proved that the Co species in the catalysts were Co3O4 phase. The interaction between Co atom and Si atom was negligible, indicating that there was almost no Co2SiO3 in the catalysts and thus the samples were easily to be reduced. The catalysts have good performance and hydrocarbon distribution which concentrated on C5～C18 in F-T synthesis, C5＋ content could be above 80%.

Key words: hollow mesoporous silica spheres (HMSS), two-solvent, Fischer-Tropsch synthesis