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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (23): 2709-2713. Previous Articles Next Articles
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李文智*,杜明霞,徐翠兰,邵 鑫,尹贻彬,赵利民
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Li, Wenzhi*,Du, Mingxia,Xu, Cuilan,Shao, Xin Yin, Yibin,Zhao, Limin
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Amylose-tris(cyclohexylcarbamate) (ACHC) coated on a kind of small particle silica gel was prepared. On this chiral stationary phase (CSP), the direct enantiomeric separation of nine chiral compounds has been achieved using n-hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers on their resolution and retention was investigated. Chromatographic behavior of chiral compounds on ACHC-CSP was compared with that on amylose-tris(3,5-dimethylphenylcarbamate) by hexane/isopropanol as the mobile phase. The result suggests that ACHC showed high chiral recognition abilities as well as amylose-tris(3,5-dimethylphenylcarbamate) in HPLC. ACHC-CSP is a suitable CSP for the optical resolution of a lot of racemates by HPLC.
Key words: amylose-tris(cyclohexylcarbamate), HPLC, enantioseparation
LI Wen-Zhi, DU Meng-Xia, XU Cui-Lan, SHAO Xin, YIN Yi-Ban, DIAO Li-Min. Enantioseparation of Chiral Compounds on Amylose-tris(cyclohexylcarbamate) Chiral Stationary Phase by High-performance Liquid Chromatography[J]. Acta Chimica Sinica, 2009, 67(23): 2709-2713.
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