Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (21): 2181-2185. Previous Articles     Next Articles

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胆固醇/两性霉素B混合单层膜相互作用的研究

常怡光,孙润广*,郝长春,薛慧君,韩涛,王小梅   

  1. (陕西师范大学物理学与信息技术学院 生物物理与生物医学工程研究室 西安 710062)
  • 投稿日期:2009-12-17 修回日期:2010-06-04 发布日期:2010-07-14
  • 通讯作者: 孙润广 E-mail:sunrunguang@snnu.edu.cn
  • 基金资助:

    国家自然科学基金;教育部高等学校博士学科点专项科研基金

Study on the Interaction Between Cholesterol and Amphotericin B in Mixed Monolayers

CHANG Yi-Guang, SUN Run-Guang, HAO Chang-Chun, XUE Hui-Jun, HAN Tao, WANG Xiao-Mei   

  1. (Laboratory of Biophysics and Biomedical Engineering, College of Physics and Information Technology, Shaanxi Normal University, Xi an 710062)
  • Received:2009-12-17 Revised:2010-06-04 Published:2010-07-14

Amphotericin B (AmB) is a widely used polyene antibiotic to treat systemic fungal infections, and the absorption process of AmB is related with biomembrane closely. In this work, the interaction between AmB and cholesterol (an important biomembrane in cell membrane) was investigated in terms of the mean surface area per molecule (A), elastic modulus (CS-1), surface excess Gibbs energy (ΔGex) and interaction parameter (α) on the basis of surface pressure-area (π-A) isotherms. The results indicate that the compressibility, stability and thermodynamic characteristics of binary mixtures of cholesterol/AmB show a marked dependence on the mole faction of AmB and the surface pressure, which has been further proved by the interaction parameter α.

Key words: amphotericin B, monolayer, elastic modulus, excess Gibbs energy, interaction parameter