Hydrothermal Synthesis and Characterization of Ag-doped Hydroxyapatite Antibacterial Agent

doi:10.6023/A1201143

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (12): 1362-1366.DOI: 10.6023/A1201143 Previous Articles Next Articles

Special Topic

银掺杂纳米羟基磷灰石抗菌粉体的水热合成及结构表征

陈华军, 徐伏秋, 薛冬, 阳永福, 张秋芬

洛阳理工学院环境工程与化学系洛阳 471023

投稿日期:2012-01-14 修回日期:2012-04-16 发布日期:2012-04-20
通讯作者: 陈华军 E-mail:chj790118@163.com
基金资助:
国家自然科学基金(No. 41101222)和河南省教育厅自然科学研究基金(No. 2006430025)资助项目.

Hydrothermal Synthesis and Characterization of Ag-doped Hydroxyapatite Antibacterial Agent

Chen Huajun, Xu Fuqiu, Xue Dong, Yang Yongfu, Zhang Qiufen

Department of Environment and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023

Received:2012-01-14 Revised:2012-04-16 Published:2012-04-20
Supported by:
Project supported by the National Natural Science Foundation of China (No. 41101222) and Henan Provincial Natural Science Research Funds (No. 2006430025).

Silver doped hydroxyapatite (HA) antimicrobial powders were synthesized by hydrothermal method using Ca(NO₃)₂?4H₂O, AgNO₃, (NH₄)₂HPO₄ as raw materials. The effects of addition of AgNO₃, reactive temperature and time on the microstructure and constituent of Ag-HA were investigated. The XRD patterns indicate that HA and Ag-HA have the same crystal structure. The calculation results of energy dispersive spectrometer (EDS) and X-ray fluorescence spectrum (XRF) indicate that Ca²⁺ in HA crystals is displaced by Ag⁺ and Ag_xCa_10－x(PO₄)₆(OH)₂ was produced at hydrothermal condition. The antibacterial test results indicate that Ag-HA have favourable antibiotic property and MIC≤50 μg/mL against Escherichia coli and Staphylococcus aureus.

Key words: Ag-HA, solid solution, hydrothermal method, characterization, antibiotic property

Cite this article

Chen Huajun, Xu Fuqiu, Xue Dong, Yang Yongfu, Zhang Qiufen. Hydrothermal Synthesis and Characterization of Ag-doped Hydroxyapatite Antibacterial Agent[J]. Acta Chimica Sinica, 2012, 70(12): 1362-1366.

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银掺杂纳米羟基磷灰石抗菌粉体的水热合成及结构表征

Hydrothermal Synthesis and Characterization of Ag-doped Hydroxyapatite Antibacterial Agent

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