[1] (a) Jenny, E. F.; Schenker, K.; Woodward, R. B. Angew. Chem., 1961, 73, 756; (b) Druey, J.; Jenny, E. F.; Schenker, K.; Woodward, R. B. Helv. Chim. Acta 1962, 45, 600.[2] Barton, D. H. R.; Gardner, J. N.; Petterson, R. C.; Stamm, O. A. J. Chem. Soc. 1962, 2708.[3] Nieuwenhuis, J.; Arens, J. F. Recl. Trav. Chim. Pays-Bas 1958, 77, 761.[4] Teufel, H.; Jenny, E. F. Tetrahedron Lett. 1971, 21, 1769.[5] Wuest, J. D. Tetrahedron 1980, 36, 2291.[6] Brown, D. G.; Hoye, T. R.; Brisbois, R. G. J. Org. Chem. 1998, 63, 1630.[7] (a) Boye, O.; Brossi, A. In The Alkaloids: Tropolonic Colchicum Alkaloids and Allo Congeners, Vol. 41, Eds.: Brossi, A.; Cordell, G. A., Academic Press, 1992, pp. 125~176; (b) Le Hello, C. In The Alkaloids: The Pharmacology and Therapeutic Aspects of Colchicine, Vol. 53, Ed.: Cordell, G. A., Academic Press, 2000, pp. 287~ 352.[8] Soltau, J.; Drevs, J. IDrugs 2004, 7, 380.[9] (a) Kristensen, B.; Noer, H.; Gramsbergen, J. B.; Zimmer, J.; Noraberg, J. Brain Res. 2003, 964, 264; (b) Zhang, S. X.; Feng, J.; Kuo, S. C.; Brossi, A.; Hamel, E.; Tropsha, A.; Lee, K. H. J. Med. Chem. 2000, 43, 167.[10] For a classic synthesis of colchicines, see: (a) Woodward, R. B. The Harvey Lecture 1963, 59, 31. For a recent review on the total synthesis of colchicine, see: (b) Graening, T.; Schmalz, H. G. Angew. Chem., Int. Ed. 2004, 43, 3230; (c) Graening, T.; Bette, V.; Neudorfl, J.; Lex, J.; Schmalz, H. G. Org. Lett. 2005, 7, 4317.[11] Anderson, J. C.; Broughton, S. Synthesis 2001, 2379.[12] Structure characterized by single crystal X-ray analysis: CCDC 891446, 891452, 891447, 891453, 891454, 891448, 891449, 891451, 891450 contain the supplementary crystallographic data for compounds 2a, 4, 5, 6, 7, 8, 11, 13 and 14, respectively. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www. ccdc. cam. ac. uk/data_request/cif.[13] (a) McDowell, P. A.; Foley, D. A.; O’Leary, P.; Ford, A.; Maguire, A. R. J. Org. Chem. 2012, 77, 2035; (b) Kennedy, M.; McKervey, M. A. J. Chem. Soc., Perkin Trans. 1 1991, 2565; (c) Duddeck, H.; Ferguson, G.; Kaitner, B.; Kennedy, M.; McKervey, M. A.; Maguire, A. R. J. Chem. Soc., Perkin Trans. 1 1990, 1055; (d) Schulman, J. M.; Disch, R. L.; Sabio, M. L. J. Am. Chem. Soc. 1984, 106, 7696; (e) Kohmoto, S.; Funabashi, T.; Nakayama, N.; Nishio, T.; Iida, I.; Kishikawa, K.; Yamamoto, M.; Yamada, K. J. Org. Chem. 1993, 58, 4764.[14] Maier, G. Angew. Chem., Int. Ed. 1967, 6, 402. |