Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (23): 2393-2403.DOI: 10.6023/A12090676 Previous Articles     Next Articles

Review

仿生超疏水性表面的生物应用

梁伟欣a,b, 张亚斌a,b, 王奔a,b, 郭志光a,b, 刘维民b   

  1. a 湖北大学功能材料绿色制备与应用教育部重点实验室 武汉 430062;
    b 中国科学院兰州化学物理研究所固体润滑国家重点实验室 兰州 730000
  • 投稿日期:2012-09-18 发布日期:2012-11-14
  • 通讯作者: 郭志光 E-mail:zguo@licp.cas.cn
  • 基金资助:

    项目受国家自然科学基金(Nos. 31070155, 11172301);湖北省杰出青年基金(No. ZRZ0048)和中国科学院“百人计划”资助.

Biological Applications of Biomimetic Superhydrophobic Surfaces

Liang Weixina,b, Zhang Yabina,b, Wang Bena,b, Guo Zhiguanga,b, Liu Weiminb   

  1. a Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062;
    b State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
  • Received:2012-09-18 Published:2012-11-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 31070155 and 11172301)、Hubei Province Funds for Distinguished Young Scientists (No. ZRZ0048) and the “Top Hundred Talents” Program of Chinese Academy of Sciences.

Nature has long served as a source of inspiration for scientists and engineers. Inspired from lotus leaf, a variety of biomimetic surfaces with superhydrophobicity have been fabricated in recent years based on the combination of surface micro- and nanostructures and chemical compositions by using many different synthetic methods. These surfaces exhibit various significant applications in anti-icing, microfluidic systems, biocompatibility and other fields. As a special material property, superhydrophobicity has been proved to be used in biomedical and biological applications in recent years. Three-dimensional superhydrophobic materials may be become an ideal carrier for drug delivery in the near future since entrapped air within the material should act as a removable barrier component to retard drug release. Superhydrophobicity property can modulate and improve the interfacial reactions of biological entities and material surfaces. For example, platelets can hardly adhere and be activated on superhydrophobic surfaces so as to avoid the blood coagulation and thrombosis, which can be applied on manmade blood vessels, artificial organ implantations and other medical devices in contact with blood. Cell and biomolecule on the surfaces with special wettabilities, e.g. superhydrophobicity, superhydrophilicity, reversible switching between superhydrophobicity and superhydrophilicity, will show different behaviors, which have been demonstrated by the investigations of protein adsorption and cell adhesion, cell and biomolecule micropatterning, antibacterial, high-throughput screening. In this review, we briefly introduce the classical wettability models, and then focus mainly on their biological applications, including drug release, blood compatibility, protein adsorption, cell behavior, biomolecule and cell micropatterning. Finally, the prospect of biomimetic superhydrophobic surface in biological applications is also proposed.

Key words: superhydrophobic, wettability, contact angle, biological applications