Acta Chimica Sinica ›› 1981, Vol. 39 ›› Issue (4): 358-361. Previous Articles     Next Articles

前列腺素中间体2-(6’-甲氧羰己基)环戊-2-烯-1-酮的合成

刘志煜, 韩卫平   

  1. 中国科学院上海有机化学研究所
  • 投稿日期:1979-04-04 发布日期:2013-06-03

THE SYNTHESIS OF A PROSTAGLANDIN INTERMEDIATE 2-(6’-METHOXYCARBONYLHEXYL)-CYCLOPENT-2-EN-1-ONE

LIU ZEI-Yu, HAN WEI-PING   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1979-04-04 Published:2013-06-03

An alternative synthesis of the title compound (1) is reported. Reaction of ethyl: 8-(chloroformyl)-octanoate(4)with the Grignard reagent of 2-(2'-bromoethyl)-1, 3-diogane (3) gave compound 5. The latter was hydrolyzed in formic acid followed by alkaline cyclization and esterification to give compound 1 in 57% yield. Minor improvement in the preparation of compound 3 was also realized.