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Acta Chimica Sinica ›› 1976, Vol. 34 ›› Issue (1): 31-37. Previous Articles     Next Articles

肿瘤的化学治疗——与放线菌素有关的化合物1,9-二[N-烷基-甲氨酰(或烷氧羰基)]-4,6-二取代基-2-氨基吩噁嗪酮-(3)的合成

李述文1, 朱珍燕2   

  1. 1. 上海药物研究所;
    2. 北京医学院药学系
  • 投稿日期:1975-08-01 发布日期:2013-06-03

TUMOUR CHEMOTHERAPY——SYNTHESIS OF COMPOUNDS RELATED TO ACTINOMYCINS 1, 9-DI-[N-ALKYLCARBAMYL(OR ALKOXY-CARBONYL)]-4, 6-DISUBSTITUTED-2-AMINO-PHENOXAZONE-(3)

LI SHU-WEN1, CHU JEN-YEN2   

  1. Shanghai Institute of Materia Medica
  • Received:1975-08-01 Published:2013-06-03

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In an attempt to modify the solubility behaviour of aotinomyains so as to improve the usefulness of this antibiotic in the treatment of tumours,the authors prepared a series of 1,9-di [N-alkyl(medium and long chain) carbamyl(or alkogy-carbonyl)]-4,6-disubstituted-2-amino-phenogazone-(3)(Ⅲ,Ⅳ,Ⅴ and Ⅵ),in which the hydrophobic groups were introduoed in place of the polypeptide moiety of the molecules of actinomycins.