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Acta Chimica Sinica ›› 1963, Vol. 29 ›› Issue (2): 109-113. Previous Articles Next Articles
韓广甸, 黄鳴龍
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HAN KUANG-TIENG, HUANG-MINLON
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Acid cleavage of β-epoxide (IX) gave ba-methyl cholestan-3β, 5a, 6β-triol (VⅡa) identical with that obtained by treatment of 3β-acetoxy-5a-hydroxy-cholestan-6one (VIb) with methyl magnesium iodide.Elimination of 5a-hydroxy of compound X with alkali gave XI which is the isomer of XⅢ obtained from XⅡ by treatment with alkali.These results confirm the conclusion of Fieser[2], Shiota[4] that Grignard reaction of 6-oxo-5a-steroid involves the least hindered a-attack by the reagent.
HAN KUANG-TIENG, HUANG-MINLON. THE CONFIGURATION OF 6-METHYL-6-HYDROXY-STEROID[J]. Acta Chimica Sinica, 1963, 29(2): 109-113.
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