Acta Chimica Sinica ›› 1963, Vol. 29 ›› Issue (2): 114-132. Previous Articles     Next Articles

肽的研究Ⅰ.带保护基的胰岛素A鏈氨端五肽的合成

汪猷1, 徐杰誠1, 陸仁荣1, 黄剛1,2, 黄敬坚1   

  1. 1. 中国科学院有机化学研究所;
    2. 中国科学院生物化学研究所
  • 投稿日期:1962-08-07 发布日期:2013-06-03

STUDIES ON PEPTIDES Ⅰ. SYNTHESIS OF PROTECTED N-TERMINAL PENTAPEPTIDES OF THE A-CHAIN OF INSULIN

WANG YU1, HSU JE-ZEN1, LOH JEN-YUNG1, HUANG KANG1,2, HUANG JING-JAIN1   

  1. 1. Institute of Organic Chemistry, Academia Sinica;
    2. Institute of Biochemistry, Academia Sinica
  • Received:1962-08-07 Published:2013-06-03

The present paper deals with the synthesis of three pentapeptides containing the same amino acid sequence of the N-terminal of the A-chain of insulin, but differing in their protecting groups.They are N-carbobenzoxyglycyl-L-isoleucyl-L-valyl-r-methyl-L-glutamyl-L-glutamine (I), N-carbobenzoxyglycyl-L-isoleucyl-L-valyl-y-methyl-L-glutamyl-L-glutamine carbo-t-butoxyhydrazide (Ⅱ) and N-carbobenzoxyglycyl-L-isoleucyl-L-valyl-L-glutamyl-L-glutamine methyl ester (Ⅲ).