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Acta Chimica Sinica ›› 1958, Vol. 24 ›› Issue (2): 162-169. Previous Articles Next Articles
高怡生, 潘百川, 陆顺兴, 陈志豪, 徐修容
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KAO YEE-SHENG, PAN PEI-CHUAN, LOH SHEUN-HSING, CHENG CHI-HAO, SHU HSIU-YUNG
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The utilization of phenylvinylketone(Ⅷ) or ρ-nitrophenylvinylketone (Ⅵ)[1] as starting material for the preparation of chloramphenicol has been described.By employing the reaction of methoxymercuration[2],both Ⅷ and Ⅵ reacted smoothly with mercury acetate in methanol and followed by successive treatment with potassium bromide and bromine to give α-bromo-β-methoxy propiophenone(ⅩⅣ,b.p.110-120°/1 mm),which had been prepared by Rebstock[3] in impure form from α-bromo-β-methoxypropionyl chloride and benzene through Friedel-Crafts reaction; or α-bromo-β-methoxy-ρ-nitropropio-phenone(Ⅸ,m.p.41-42.5°).
KAO YEE-SHENG, PAN PEI-CHUAN, LOH SHEUN-HSING, CHENG CHI-HAO, SHU HSIU-YUNG. SYNTHESIS OF INTERMEDIATES FOR THE PREPARATION OF CHLORAMPHENICOL[J]. Acta Chimica Sinica, 1958, 24(2): 162-169.
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