Recent Advances in Magnetosensing Cryptochrome Model Systems

doi:10.6023/A18040173

Acta Chim. Sinica ›› 2018, Vol. 76 ›› Issue (8): 597-604.DOI: 10.6023/A18040173 Previous Articles Next Articles

Review

隐花色素磁感应模型体系的研究进展

郭锦平^a, 万浩宇^a, Jörg Matysik(誉宫)^b, 王孝杰^a

a 国防科技大学文理学院生物与化学系长沙 410073;
b 莱比锡大学分析化学系莱比锡(德国) 04103

投稿日期:2018-04-27 发布日期:2018-06-22
通讯作者: 王孝杰 E-mail:wangxiaojie@nudt.edu.cn
作者简介:郭锦平,男,2016年于南开大学获得理学学士学位,同年进入国防科技大学攻读硕士学位,指导老师为王孝杰副教授,研究方向为隐花色素模型化合物的合成与磁感应研究;万浩宇,男,国防科技大学应用化学专业2014级本科生,目前从事隐花色素模型化合物的合成相关工作;Jörg Matysik,男,博士,现任德国莱比锡大学分析化学研究所所长,全职教授.1964年出生于德国埃森.;王孝杰,男,博士,副教授,1970年10月出生于内蒙古包头.于1992和1996年毕业于国防科技大学应用化学专业,分别获学士、硕士学位,2007年毕业于国防科技大学材料科学与工程专业,获博士学位.1992年至今在国防科技大学从事化学方面的教学科研工作.
基金资助:
项目受国防科技大学校科研计划（No.ZK16-03-55）资助.

Recent Advances in Magnetosensing Cryptochrome Model Systems

Guo Jinping^a, Wan Haoyu^a, Jörg Matysik^b, Wang Xiaojie^a

a Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha 410073;
b Institut für Analytische Chemie, Universität Leipzig, Linnéstr. 3, 04103 Leipzig, Germany

Received:2018-04-27 Published:2018-06-22
Contact: 10.6023/A18040173 E-mail:wangxiaojie@nudt.edu.cn
Supported by:
Project supported by the National University of Defense Technology Research Foundation (No. ZK16-03-55).

Although it has been widely and deeply studied for half a century that many animals sense the Earth's magnetic field for navigation, the exact mechanism of magnetoreception is still largely unclear. In 1978, Schulten et al. proposed that the radical-pair mechanism provides the operational principle of light-depended biological magnetoreception. This hypothesis has been developed in recent years, assuming that the flavoprotein and blue-light photoreceptor cryptochrome is the biological magnetosensitive molecule undergoing light-triggered radical-pair dynamics. Evidence is accumulating in favor of this radical-pair-based magnetoreception and the cryptochrome hypothesis. However, Complex in vivo and photochemical properties of cryptochrome hamper to identify the exact mechanism of biological magnetoreception. According to the radical-pair mechanism, magnetic fields may alter the rate and yields of chemical reactions involving spin-correlated radical pairs (SCRP) as intermediates. Such magnetic field effects (MFE) have been studied in detail in a variety of chemical systems both exper-imentally and theoretically. To improve the understanding of the radical-pair mechanism and the magnetosensitivity of cryp-tochrome, several artificial model systems have been constructed and studied by different analytical means. Model systems greatly simplify the complexity of the biological environment and allow for systematic variation of properties. Based on the research of domestic and foreign scholars, we here review studies on the radical-pair-based biological magnetoreception and magnetosensitivity of cryptochrome, and we discuss the recent progresses on three major artificial model systems:(1) a variety of flavin-based radical pair systems in mixture solution, micellar solution or protein environment; (2) chemical magnetosensitive model molecules, e.g. flavin adenine dinucleotide (FAD), a carotenoid-porphyrin-fullerene triad (C-P-F) and a flavin-tryptophan dyad (F10T); (3) artificial flavoprotein magnetosensors, i.e., a family of simplified, adaptable proteins-flavomaquettes. We also briefly summarize characteristics and advantages of those different artificial model systems and raise some key scientific issues in the further research on radical-pair-based biological magnetoreception.

Key words: cryptochrome, biological magnetoreception, radical-pair mechanism, flavin, model systems

Cite this article

Guo Jinping, Wan Haoyu, Jörg Matysik, Wang Xiaojie. Recent Advances in Magnetosensing Cryptochrome Model Systems[J]. Acta Chim. Sinica, 2018, 76(8): 597-604.

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隐花色素磁感应模型体系的研究进展

Recent Advances in Magnetosensing Cryptochrome Model Systems

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