Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (11): 1150-1163.DOI: 10.6023/A20060253 Previous Articles     Next Articles



闫琳, 任永硕, 王雪靖, 穆韡, 韩晓军   

  1. 哈尔滨工业大学 城市水资源与水环境国家重点实验室 化工与化学学院 哈尔滨 150001
  • 投稿日期:2020-06-20 发布日期:2020-08-11
  • 通讯作者: 穆韡, 韩晓军;
  • 作者简介:闫琳,硕士研究生,2018年毕业于济南大学,获理学学士学位.2018年起于哈尔滨工业大学化工与化学学院攻读硕士学位.目前主要研究方向为凝聚体及其在人造细胞领域的应用;任永硕,博士研究生.2019年毕业于哈尔滨工业大学,获工学学士学位.2019年起于哈尔滨工业大学攻读博士学位.目前主要研究方向为人造细胞的磁控阵列的构建及基于磷脂合成的可持续生长分裂的人造细胞体系的研究;王雪靖,博士后.2019年毕业于哈尔滨工业大学,获得工学博士学位.研究方向为功能化磷脂囊泡及磷脂囊泡阵列的构建,以及磷脂囊泡在人造细胞领域的应用;韩晓军,教授,博士生导师,英国皇家化学会会士,哈尔滨工业大学化工与化学学院生物分子与化学工程系主任.主持承担国家自然科学基金等基金项目20多项.迄今在Nat.Commun.,Adv.Mater.,J.Am.Chem.Soc.等刊物上发表SCI论文160多篇.目前主要研究方向包括人造细胞、药物控释等.
  • 基金资助:

Coacervate and Its Application in the Field of Artificial Cells

Yan Lin, Ren Yongshuo, Wang Xuejing, Mu Wei, Han Xiaojun   

  1. State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001
  • Received:2020-06-20 Published:2020-08-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21773050, 21929401) and the Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars (No. JC2018003).

The origin of life attracts more and more attentions of researchers. Synthetic biologists are devoting to construct a simple and rational system which can exist in primitive earth. Coacervate is a phase separation system which is formed by the interactions of polyelectrolyte. It's a rational protocell model. So far, coacervate has been found to present as membraneless organelles in natural cells. Therefore, the construction of coacervate as artificial organelles is emerging. The formation mechanism, characteristics and categories of coacervate are reviewed in this paper. Additionally, the applications of coacervate as protocell and artificial organelles are summarized. The existing scientific problems and the future development directions are provided at the end of this paper.

Key words: coacervate, artificial cells, liquid/liquid phase separation, electrostatic interaction, artificial organelle, collective behavior