Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications

doi:10.6023/A20080370

Acta Chimica Sinica ›› 2021, Vol. 79 ›› Issue (1): 1-9.DOI: 10.6023/A20080370 Previous Articles Next Articles

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基于壳聚糖物理网络的高强韧双网络水凝胶的构建、调控与应用

杨艳宇^a^,^b, 王星^b^,^*(), 吴德成^b^,^c^,^*()

a 郑州大学材料科学与工程学院郑州 450001)
(
b 中国科学院化学研究所北京 100190)
(
c 南方科技大学生物医学工程系深圳 518055

投稿日期:2020-08-16 发布日期:2020-09-16
通讯作者: 王星, 吴德成

作者简介:

杨艳宇, 2017年博士毕业于中国科学院化学研究所, 高分子化学与物理专业, 导师为吴德成研究员, 现为郑州大学副教授, 研究方向为高机械性能水凝胶材料的构筑与功能化研究.

王星, 中国科学院化学研究所副研究员, 2014年于中国科学院化学研究所取得博士学位, 研究方向为医用高分子水凝胶的可控制备、功能构筑及应用研究.

吴德成, 中国科学院化学研究所研究员、南方科技大学生物医学工程系讲席教授. 研究方向为生物医用高分子、医用敷料/耗材、生物成像、药物输运和组织工程.

* E-mail: wangxing@iccas.ac.cn; dcwu@iccas.ac.cn

基金资助:
国家自然科学基金(Nos. 51803188); 国家自然科学基金(51973226); 国家自然科学基金(21725403)

Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications

Yanyu Yang^a^,^b, Xing Wang^b^,^*(), Decheng Wu^b^,^c^,^*()

a College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China)
(
b Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China)
(
c Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China

Received:2020-08-16 Published:2020-09-16
Contact: Xing Wang, Decheng Wu
Supported by:
the National Natural Science Foundation of China(Nos. 51803188); the National Natural Science Foundation of China(51973226); the National Natural Science Foundation of China(21725403)

Double-network (DN) hydrogels are composed of two asymmetric networks with contrasting properties, wherein the rigid and brittle network serving as sacrificial bonds effectively dissipates energy to enhance the mechanical performance. The first reconstructable physical network endows the DN hydrogels with outstanding anti-soften and mechanical stability. However, the monotonous type of physical networks and the difficulty in tailoring structure and mechanics greatly limit the development and application of DN hydrogels. Focusing on these problems, we have fabricated the rigid and brittle chitosan physical network with adjustable network type, structure and property and further constructed various chitosan-based DN hydrogels with high mechanical performance and tunable mechanics. The hydrogels were potential materials for anti-freezing dresses, biomedical materials, flexible electronics and wearable devices. The universal strategy of constructing chitosan-based DN hydrogels was beneficial for developing various functional and high-mechanical hydrogels and broadening their applications.

Key words: chitosan physical network, strong and tough hydrogel, structural and mechanical regulation, freezing tolerance, flexible wearable device

Cite this article

Yanyu Yang, Xing Wang, Decheng Wu. Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications[J]. Acta Chimica Sinica, 2021, 79(1): 1-9.

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Fig. & Tab. 12

Figure 1. The high mechanical performance, tunable structure and applications of chitosan-based DN hydrogel

Figure 2. Structure of chitosan chain

Figure 3. Multi-membrane chitosan crystal network hydrogel[9]

Figure 4. Scheme of chitosan ionic network hydrogel[11]

Figure 5. Scheme of fabrication of chitosan-polyacrylamide microcrystalline-covalent DN hydrogel[12]

Figure 6. Mechanical performance of chitosan-polyacrylamide microcrystalline-covalent DN hydrogel: (A) load-bearing capacity, (b) rolling resistance, (C) crack blunting, (D) energy dissipation and (E) self-recoverability[12]

Figure 7. (A) Scheme of fabrication of chitosan-polyacrylamide chain-entanglement-covalent DN hydrogel and (B, C) its swelling behavior in water[12]

Figure 8. (A) Structure and (B) high elasticity of chitosan-polyacrylamide ionic-covalent DN hydrogel. (C) Swelling behavior and (D, E) mechanical performance of the original and swollen hydrogel[20]

Figure 9. Flexible adjustment of structure and mechanics of hydrogel[20]

Figure 10. (A) Energy dissipation mechanism, (B) ionic conductivity and (C) anti-freezing performance of high-mechanical chitosan-based DN hydrogel[27]

Figure 11. CS-PHEAA DN hydrogel as ant-freezing dressing to protect skin from frostbite. (A) Schematic diagram of frostbite model. Photos of (B) skin, (C) cold coins (top) and hydrogels (bottom) after coving the cold coin for 30 s. Histological microscopy images of (D) bare skin, (E) skin protected by composite hydrogel and (F) skin protected by DN hydrogel[27]

Figure 12. Chitosan-based DN hydrogel serving as anti-freezing and multi-model wearable device to detect various human motions[27- 28]

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基于壳聚糖物理网络的高强韧双网络水凝胶的构建、调控与应用

Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications

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