Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases★

doi:10.6023/A23040144

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (8): 1043-1051.DOI: 10.6023/A23040144 Previous Articles Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Review

纳米酶介导的炎性肠道疾病治疗研究进展^★

陈其文, 张先正^*()

武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室武汉 430072

投稿日期:2023-04-19 发布日期:2023-09-14

作者简介:

陈其文, 武汉大学博士后, 合作导师为张先正教授. 分别于2015年、2018年在西北农林科技大学获得学士及硕士学位; 2021年在武汉大学获得博士学位, 同年在武汉大学进行博士后研究工作. 主要研究方向为构建微生物基活性生物材料用于疾病治疗.

张先正, 武汉大学教授, 1994、1997、2000年相继于武汉大学获学士、硕士和博士学位. 2000年9月~2001年8月新加坡材料研究所Research Associate. 2001年9月~2004年8月美国康奈尔大学博士后. 自2004年9月起在武汉大学化学与分子科学学院任教授, 主要从事生物医用高分子材料的研究.

^★庆祝《化学学报》创刊90周年.

基金资助:
项目受国家重点研发计划(2019YFA0905603); 国家自然科学基金(22135005); 国家自然科学基金(52131302); 国家自然科学基金(51833007); 博士后科学基金(2021TQ0250); 博士后科学基金(2022M712456)

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★

Qiwen Chen, Xianzheng Zhang()

Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

Received:2023-04-19 Published:2023-09-14
Contact: *E-mail: xz-zhang@whu.edu.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
National Key Research and Development Program of China(2019YFA0905603); National Natural Science Foundation of China(22135005); National Natural Science Foundation of China(52131302); National Natural Science Foundation of China(51833007); China Postdoctoral Science Foundation(2021TQ0250); China Postdoctoral Science Foundation(2022M712456)

Recently, the increasing morbidity of inflammatory bowel diseases (IBD) has become a threat to public health around the world. At present, anti-inflammatory drugs, antibiotics, biological antibodies, and immunomodulators are widely used to treat IBD through suppressing inflammation response, but the therapeutic effects are not always satisfied. Biological enzymes have highly efficient and specific catalytic activity, which has aroused extensive research interest in diagnosis and treatment of inflammatory diseases. However, bioenzymes are difficult to be purified and are easy to be inactivated within organism, which limits its further applications. Compared with bioenzymes, nanozymes have simple preparation procedure, stable structure and high enzyme-like catalytic activity. Very recently, nanozymes have been widely used in the field of biomedicine, such as anti-cancer, antibacterial, anti-inflammation and so on. In this review, recent research advances of nanozymes for treatment of IBD are summarized by introducing typical studies, focusing on the composition, synthesis methods, catalytic properties and therapeutic mechanisms of the used nanozymes. This review also discusses the limitations of the current application of nanozymes for the treatment of IBD, and the prospect of the future construction of nanozymes for treatment of IBD.

Key words: nanozymes, catalytic activity, anti-inflammation, intestinal inflammation

Cite this article

Qiwen Chen, Xianzheng Zhang. Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★[J]. Acta Chimica Sinica, 2023, 81(8): 1043-1051.

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Nanozymes	Catalytic activity	Anti-inflammation application	Ref.
Pt NPs	SOD, CAT, POD-like	Human Cerebral Cavernous Malformation (CCM) disease	[34]
PVP-IrNPs	CAT, POD-like	Cell protection	[35]
Rh-PEG NDs	SOD, CAT-lile, and •OH, ONOO⁻，•NO scavenging activity	IBD therapy	[36]
Single-atom Fe-N₄	SOD-like, CAT-like	Cell protection	[37]
Mo NPs	N-Acetyl cysteine-like	Anti-tumor cell	[38]
Fe₃O₄ NPs	CAT-like	Anti-aging	[39]
MnO₂ NPs	SOD, CAT-like	Cell protection	[40]
Mn₃O₄ NPs	SOD, CAT, GPx-like, and •OH scavenging activity	Parkinson’s disease	[41]
CeO₂ NPs	SOD, CAT-like	Neuroprotective effect	[42]
MoS₂ NPs	SOD, CAT-like	Osteoarthritis	[43]
Cu_xO NPs	SOD, CAT, and GPx-like	Parkinson’s disease	[44]
CuTA	SOD-like, CAT-like, and •OH scavenging activity	Lung destruction	[45]
NiCo₂O₄@PVP	•OH, $\mathrm{O}_{2}^{-}$ and H₂O₂ scavenging activity	IBD therapy	[46]
PtPdMo trim	POD, CAT-like, and •OH, ¹O₂, •NO scavenging activities	Brain injury	[47]
Carbogenic nanozyme	SOD, CAT-like •NO and ONOO-scavenging activities	Traumatic brain injury	[48]
C-dots nanozyme	SOD-like	IBD therapy	[49]
Melanin NPs	SOD-like	Ischemic stroke	[50]
Se-CQDs	•OH scavenging activity	Cell protection	[51]
Se@Pda	GPx-like	Anti-inflammation	[52]

Nanozymes	Catalytic activity	Anti-inflammation application	Ref.
Pt NPs	SOD, CAT, POD-like	Human Cerebral Cavernous Malformation (CCM) disease	[34]
PVP-IrNPs	CAT, POD-like	Cell protection	[35]
Rh-PEG NDs	SOD, CAT-lile, and •OH, ONOO⁻，•NO scavenging activity	IBD therapy	[36]
Single-atom Fe-N₄	SOD-like, CAT-like	Cell protection	[37]
Mo NPs	N-Acetyl cysteine-like	Anti-tumor cell	[38]
Fe₃O₄ NPs	CAT-like	Anti-aging	[39]
MnO₂ NPs	SOD, CAT-like	Cell protection	[40]
Mn₃O₄ NPs	SOD, CAT, GPx-like, and •OH scavenging activity	Parkinson’s disease	[41]
CeO₂ NPs	SOD, CAT-like	Neuroprotective effect	[42]
MoS₂ NPs	SOD, CAT-like	Osteoarthritis	[43]
Cu_xO NPs	SOD, CAT, and GPx-like	Parkinson’s disease	[44]
CuTA	SOD-like, CAT-like, and •OH scavenging activity	Lung destruction	[45]
NiCo₂O₄@PVP	•OH, $\mathrm{O}_{2}^{-}$ and H₂O₂ scavenging activity	IBD therapy	[46]
PtPdMo trim	POD, CAT-like, and •OH, ¹O₂, •NO scavenging activities	Brain injury	[47]
Carbogenic nanozyme	SOD, CAT-like •NO and ONOO-scavenging activities	Traumatic brain injury	[48]
C-dots nanozyme	SOD-like	IBD therapy	[49]
Melanin NPs	SOD-like	Ischemic stroke	[50]
Se-CQDs	•OH scavenging activity	Cell protection	[51]
Se@Pda	GPx-like	Anti-inflammation	[52]

纳米酶介导的炎性肠道疾病治疗研究进展^★

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★

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[15]	SHEN Xing-Can^,1 GUO Wei-Min¹ LIANG Hong^,1 ZHANG Lai-Jun^1,2 HU Rui-Xiang WANG Zhuo-Yuan. Synergistic Effects of Microwave Doped-Ag on the Phase Transformation and Photocatalytic Activity of Titania Nanocrystallite [J]. Acta Chimica Sinica, 2008, 66(1): 49-55.

纳米酶介导的炎性肠道疾病治疗研究进展★

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases★

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Abstract

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Fig. & Tab. 8

References 126

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纳米酶介导的炎性肠道疾病治疗研究进展^★

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★