Research Progress in Sonochemistry for Biomedical Applications★

doi:10.6023/A23040129

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (7): 836-842.DOI: 10.6023/A23040129 Previous Articles Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Review

超声化学在生物医学中应用的研究进展^★

罗楚文^a^,^b, 孔超颖^a^,^b, 汤朝晖^a^,^b^,^c^,^*()

a 中国科学院长春应用化学研究所中国科学院生态环境高分子材料重点实验室长春 130022
b 中国科学技术大学应用化学与工程学院合肥 230026
c 吉林省生物医用高分子材料工程实验室长春 130022

投稿日期:2023-04-11 发布日期:2023-06-16

作者简介:

罗楚文, 2022年至今硕士就读于中国科学院长春应用化学研究所, 专业方向为高分子化学与物理.

孔超颖, 2020年至今博士就读于中国科学院长春应用化学研究所, 材料化学工程专业, 主要从事于超声激活抗肿瘤前药设计的研究.

汤朝晖, 中国科学院长春应用化学研究所研究员, 博士生导师. 曾在英国帝国理工学院和美国纽约州立大学石溪分校做博士后. 主要从事高分子载体抗肿瘤纳米药物研究. 在Adv. Mater., Adv. Sci., Prog. Polym. Sci., Chem. Sci., Biomateri- als, Nano Lett., J. Control. Release 等知名期刊发表学术论文 120余篇.

^★庆祝《化学学报》创刊90周年.

基金资助:
中国科技部(2022YFE0110200); 国家自然科学基金(52025035)

Research Progress in Sonochemistry for Biomedical Applications^★

Chuwen Luo^a^,^b, Chaoying Kong^a^,^b, Zhaohui Tang^a^,^b^,^c()

a Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

Received:2023-04-11 Published:2023-06-16
Contact: *E-mail: ztang@ciac.ac.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
Ministry of Science and Technology of China(2022YFE0110200); National Natural Science Foundation of China(52025035)

Ultrasound is a kind of mechanical wave, whose frequency exceeds the upper limit of human hearing. Ultrasound has high energy and penetration, which can pierce the barrier of biological soft tissue and induce the occurrence of chemical reactions. In recent years, sonochemistry has been increasingly used in biomedical research, providing a new focus for the development of biomedicine. This review is mainly divided into three parts, the mechanochemistry of ultrasound, the sonochemistry assisted by sonosensitizers, and the cavitation effect of ultrasound, to describe the research progress in sonochemistry for biomedical applications.

Key words: ultrasound, biomedicine, mechanochemistry, sonosensitizer, ultrasonic cavitation

Cite this article

Chuwen Luo, Chaoying Kong, Zhaohui Tang. Research Progress in Sonochemistry for Biomedical Applications^★[J]. Acta Chimica Sinica, 2023, 81(7): 836-842.

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	优势/劣势	类型
有机声敏剂	优势: 合成简单, 生物降解性好, ROS产率高	共轭高分子^[33,36]
有机声敏剂	劣势: 稳定性较差, 光毒性高, 水溶性相对较差	有机配合物^[38-39]
无机声敏剂	优势: 纳米结构可控, 稳定性高, 光毒性低, 水溶性好劣势: 合成相对困难, 生物降解性低, ROS产率小	压电效应激活的声敏剂^[49]
		声电耦合激活的声敏剂^[51]
		声致发光激活的声敏剂^[54⇓-56]
复合型声敏剂	优势: 取长补短, 能最大程度发挥出声敏剂本身的优势劣势: 体系相对复杂	弥补缺陷的复合型声敏剂^[59]
复合型声敏剂	优势: 取长补短, 能最大程度发挥出声敏剂本身的优势劣势: 体系相对复杂	拓展功能的复合型声敏剂^[62]

	优势/劣势	类型
有机声敏剂	优势: 合成简单, 生物降解性好, ROS产率高	共轭高分子^[33,36]
有机声敏剂	劣势: 稳定性较差, 光毒性高, 水溶性相对较差	有机配合物^[38-39]
无机声敏剂	优势: 纳米结构可控, 稳定性高, 光毒性低, 水溶性好劣势: 合成相对困难, 生物降解性低, ROS产率小	压电效应激活的声敏剂^[49]
		声电耦合激活的声敏剂^[51]
		声致发光激活的声敏剂^[54⇓-56]
复合型声敏剂	优势: 取长补短, 能最大程度发挥出声敏剂本身的优势劣势: 体系相对复杂	弥补缺陷的复合型声敏剂^[59]
复合型声敏剂	优势: 取长补短, 能最大程度发挥出声敏剂本身的优势劣势: 体系相对复杂	拓展功能的复合型声敏剂^[62]

超声化学在生物医学中应用的研究进展^★

Research Progress in Sonochemistry for Biomedical Applications^★

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[1]	Wenjun Wu, Yuting Li, Xi Feng, Wenxing Ding. Perovskite Dual-function Passivator: Room Temperature Ionic Liquid Obtained from Mechanochemical Preparation [J]. Acta Chimica Sinica, 2022, 80(11): 1469-1475.
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[6]	WANG Jun*^,1, XU Liang, ZHANG Zhao-Hong², WANG Lei, ZHANG Xiang-Dong, PAN Zhi-Jun, TONG Jian, ZHANG Peng. Investigation on Damage of Bovine Serum Albumin by Hematoporphyrin under Ultrasonic Irradiation [J]. Acta Chimica Sinica, 2005, 63(20): 1921-1926.
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超声化学在生物医学中应用的研究进展★

Research Progress in Sonochemistry for Biomedical Applications★

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超声化学在生物医学中应用的研究进展^★

Research Progress in Sonochemistry for Biomedical Applications^★