Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids★

doi:10.6023/A23050246

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (10): 1438-1446.DOI: 10.6023/A23050246 Previous Articles Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Review

器官靶向的聚合物核酸载体研究进展^★

溥旭, 李泽娟, 石隽秋, 朱云卿^*(), 杜建忠^*()

同济大学材料科学与工程学院高分子材料系上海 201804

投稿日期:2023-05-24 发布日期:2023-07-03
通讯作者: 朱云卿, 杜建忠

作者简介:

溥旭, 同济大学材料科学与工程学院高分子材料系2021级硕士研究生, 研究方向为基于可降解阳离子聚合物的淋巴结靶向核酸递送载体.

李泽娟, 同济大学材料科学与工程学院高分子材料系2022级硕士研究生, 研究方向为基于可降解阳离子聚合物的骨靶向核酸递送载体.

石隽秋, 同济大学材料科学与工程学院高分子材料系2020级博士研究生, 研究方向为非侵入性可降解核酸递送系统的构建与研究.

朱云卿, 2016 年在英国帝国理工大学获得博士学位. 2017~2019年分别在英国牛津大学和帝国理工大学从事博士后研究工作, 2019年6月入职同济大学. 同济大学青年百人计划研究员, 博士生导师. 主要从事环境友好高分子材料研究, 主持了国家自然科学基金青年科学基金、面上项目等. 以第一/通讯作者在Nature, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等期刊发表SCI论文30多篇, 包括2篇ESI热点论文.

杜建忠, 中国科学院化学研究所博士(2004年), 谢菲尔德大学、剑桥大学博士后(2004~2010年), 洪堡学者(2006年), 东方学者(2009年). 同济大学长聘特聘教授、学术委员会委员、高分子材料系主任、博士生导师. 英国皇家化学会会士、中国化学会高分子学科委员会委员、中国生物材料学会生物医用高分子材料分会委员、Biomacromolecules等期刊顾问编委. 主要研究领域为高分子化学与物理、生物医用材料, 已在J. Am. Chem. Soc.等期刊发表150多篇论文, 获国家杰出青年科学基金(2019年)、国家科技进步奖二等奖(3/15)、中国侨界贡献奖一等奖、同济大学首届“卓越”研究生导学团队标兵、同济大学“十三五”科研工作先进个人、2023年同济大学青年五四奖章(集体)等.

^★庆祝《化学学报》创刊90周年.

基金资助:
国家杰出青年科学基金(21925505); 上海市科委国际合作项目(21520710100); 上海市教委科研创新计划重大项目(2023ZKZD28); 国家自然科学基金(51903190); 国家自然科学基金(22175131)

Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids^★

Xu Pu, Zejuan Li, Junqiu Shi, Yunqing Zhu(), Jianzhong Du()

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804

Received:2023-05-24 Published:2023-07-03
Contact: Yunqing Zhu, Jianzhong Du
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
National Science Fund for Distinguished Young Scholars, NSFC(21925505); Shanghai International Scientific Collaboration Fund(21520710100); Innovation Program of Shanghai Municipal Education Commission(2023ZKZD28); National Natural Science Foundation of China(51903190); National Natural Science Foundation of China(22175131)

Nucleic acids-based therapy has been developed rapidly in recent years and the effective treatment is closely related to the safe and efficient delivery of nucleic acids. On the one hand, it is difficult for nucleic acids to penetrate cell membranes and express. On the other hand, unlike other drugs, some genetic therapeutics work at the condition of expressing in specific organ or cells. Therefore, delivery vectors are particularly important: they are expected to protect nucleic acids and achieve efficient transfection. Besides, they should be able to target specific sites to increase the probability of nucleic acid expression in target cells. Given the importance of polymer nucleic acid vectors, in this review, the research progress of polymeric delivery systems is summarized, including how to achieve aggregation from the administration site to the target site, and the state of the art of organ-targeting polymer nucleic acid vectors. Finally, the perspective of organ-targeting polymeric nucleic acid vectors is given.

Key words: organ targeting, polymeric delivery vectors for nucleic acids, self-assembly

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Xu Pu, Zejuan Li, Junqiu Shi, Yunqing Zhu, Jianzhong Du. Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids^★[J]. Acta Chimica Sinica, 2023, 81(10): 1438-1446.

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Fig. & Tab. 11

Figure 1. Commonly used poly(amino acid)-based delivery vectors

Figure 2. Commonly used polyethylenimine-based delivery vectors

Figure 3. Commonly used polyester-based delivery vectors

Figure 4. Commonly used polyamidoamine-based delivery vectors

Figure 5. Schematic of formation of the protein corona[26]. Copyright? 2020, American Chemical Society

Figure 6. Mononuclear phagocyte system[35]. Copyright? 2017, John Wiley and Sons

Figure 7. Schematic of endosomal escape[57]. Copyright? 2022, John Wiley and Sons

Figure 8. PEGylated PEI complexes target the lungs[53]. Copyright? 2020, American Chemical Society

Figure 9. Hyperbranched poly(β-amino ester)s for respiratory delivery[54]. Copyright?2019, John Wiley and Sons

Figure 10. Schematic representation of the vector that could be targeted to the lung after intravenous administration[52]. Copyright?2016, John Wiley and Sons

Figure 11. Schematic representation of cationic polymers with zwitterionic side chains that enable spleen and lymph nodes targeting[73]. Copyright?2021, American Chemical Society

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器官靶向的聚合物核酸载体研究进展^★

Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids^★

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器官靶向的聚合物核酸载体研究进展★

Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids★

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器官靶向的聚合物核酸载体研究进展^★

Recent Advances in Organ-Targeting Polymeric Delivery Vectors for Nucleic Acids^★