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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 06: 714 - 720

DOI: https://doi.org/10.6023/A1107051

Special Topic

Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures

  • Wei Qiaona ,
  • Ma Lin ,
  • Huang Aimin ,
  • Yang Hua ,
  • Gong Zhuping ,
  • Qiang Panpan ,
  • Zhang Li
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  • College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004

Received date: 2011-07-05

  Revised date: 2011-11-16

  Online published: 2011-12-09

Supported by

Project supported by the National Natural Science Foundation of China (No. 21063002), Natural Science Foundation of Guangxi Province (No. 2011jjC30004) and Post-graduate Innovation Program of Guangxi Province (No. 105931003028).

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Abstract

Silk fibroin (SF) films were prepared using a casting method and the structural change owing to treatment with methanol-water mixtures of different concentrations was investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results were used to reveal the influence of structure on the release dynamics of Rhodamine B, a model compound loaded in the SF matrix. In methanol concentration ranging from 50% to 90%, the content of silk Ⅱ crystalline structure, constituted by β-sheet, first increased and then decreased with increasing methanol concentration in the mixtures, reaching a maximum around 80%. It was found that Rhodamine B released from the SF film via Fickian mechanism, of which the diffusional exponent increased with increasing β-sheet content in the matrix, suggesting that the silk Ⅱ crystal could be used as natural regulator for drug release from SF material.

Key words： silk fibroin; controlled release; structural change

Cite this article

Wei Qiaona , Ma Lin , Huang Aimin , Yang Hua , Gong Zhuping , Qiang Panpan , Zhang Li . Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures[J]. Acta Chimica Sinica, 2012 , 70(06) : 714 -720 . DOI: 10.6023/A1107051

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