Synthesis and Characterization of 5-phosphonyl 3-arylisoxazoline

doi:10.6023/cjoc1111271

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1336-1339.DOI: 10.6023/cjoc1111271 Previous Articles Next Articles

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5-磷酰基-3-芳基异噁唑啉的合成及结构表征

张长水^a, 叶勇^b

a 河南科技大学化工与制药学院洛阳 471003;
b 郑州大学化学系河南省磷化工工程技术研究中心郑州 450052

收稿日期:2011-11-27 修回日期:2011-12-30 发布日期:2012-03-31
通讯作者: 叶勇 E-mail:yeyong@zzu.edu.cn
基金资助:
国家自然科学基金(No. 20972143)资助项目.

Synthesis and Characterization of 5-phosphonyl 3-arylisoxazoline

Zhang Changshui^a, Ye Yong^b

a Chemical Engineering & Pharmaceutics College, Henan University Of Science & Technology, Luoyang 471003;
b Phosphorus Chemical Engineering Research Center of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou 450052

Received:2011-11-27 Revised:2011-12-30 Published:2012-03-31
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20972143).

A series of regioselectively isoxazolines were synthesized through cycloaddition reaction of nitrile oxides with vinylphosphonate. The structure of title compound was proved as 5-phosphonyl isoxazoline by X-ray crystallography of compound 3c. Their structures were confirmed by NMR, ESI-MS and elemental analysis. We have tested suppression of the NIs, and found they can inhibit neuraminidase.

Key words: Vinylphosphonates, nitrile oxides, 1,3-Dipolar cycloadditions, isoxazoline

Cite this article

Zhang Changshui, Ye Yong. Synthesis and Characterization of 5-phosphonyl 3-arylisoxazoline[J]. Chin. J. Org. Chem., 2012, 32(07): 1336-1339.

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5-磷酰基-3-芳基异噁唑啉的合成及结构表征

Synthesis and Characterization of 5-phosphonyl 3-arylisoxazoline

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