Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2742-2754.DOI: 10.6023/cjoc202003056 Previous Articles     Next Articles


刘颖杰, 孟建萍, 李晨, 林立青, 许颖   

  1. 哈尔滨商业大学药学院 哈尔滨 150076
  • 收稿日期:2020-03-24 修回日期:2020-05-03 发布日期:2020-05-29
  • 通讯作者: 刘颖杰, 许颖;
  • 基金资助:

Progress in the Synthesis of Isoxazoline Derivatives by Cycloylation of Allyl Oxime

Liu Yingjie, Meng Jianping, Li Chen, Lin Liqing, Xu Ying   

  1. School of Pharmacy, Harbin University of Commerce, Harbin 150076
  • Received:2020-03-24 Revised:2020-05-03 Published:2020-05-29
  • Supported by:
    Project supported the Natural Science Foundation of Heilongjiang Province (No. YQ2019B004), the Youth Reserve Talent Program of Harbin University of Commerce (No. YQ2019CX36) and the Youth Innovation Talent Project of Harbin University of Commerce (No. 2016QN056).

Isoxazoline is an important class of heterocyclic ring with a wide range of biological characteristics, which is the key structural framework of many natural products and bioactive compounds. The effective synthetic method of isoxazoline has been the subject of extensive research. In this review, the latest progress in the synthesis of various functionalized isoxazoline by allyl oxime, involving the radical oxidation/cyclization reaction in the presence of oxidants is described. These reactions are usually carried out under neutral conditions using readily available oxidants and different metals or metal-free catalysis.

Key words: isoxazoline, allyl oxime, cyclization reaction, metal catalysis