Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2223-2230.DOI: 10.6023/cjoc201206026 Previous Articles     Next Articles

Reviews

Vilsmeier试剂近年来在环化反应中的应用

钱晓庆, 周恒, 詹晓平, 刘增路, 毛振民   

  1. 上海交通大学药学院 上海 200240
  • 收稿日期:2012-06-26 修回日期:2012-08-13 发布日期:2012-08-15
  • 通讯作者: 毛振民, 钱晓庆 E-mail:zmmao@sjtu.edu.cn;qianxiaoqing2000@yahoo.com.cn
  • 基金资助:

    国家科技重大新药创制专项(No. 2010ZX09401-404)资助项目.

Application of Vilsmeier Reagents in Cyclization in Recent Years

Qian Xiaoqing, Zhou Heng, Zhan Xiaoping, Liu Zenglu, Mao Zhenmin   

  1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240
  • Received:2012-06-26 Revised:2012-08-13 Published:2012-08-15
  • Supported by:

    Project supported by the Significant New Drugs Creation Special Science and Technology Major of China (No. 2010ZX09401-404).

The Vilsmeier-Hack reaction has historically been a topic of great interest to organic chemists, and it continues to attract considerable attention. The Vilsmeier-Hack reaction provides a facile entry into large numbers of aromatic and heteroaromatic systems. Vilsmeier reagents generated from amides and halides have been found to be very important in organic synthesis. Acylation, chlorination, chloroformylation, aromatization, rearrangement, dehydration and cyclization are the most reactions of Vilsmeier reagents. The application of Vilsmeier reagents in cyclization is introduced.

Key words: Vilsmeier-Hack reaction, Vilsmeier reagents, cyclization, application