Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (2): 644-649.DOI: 10.6023/cjoc202308010 Previous Articles     Next Articles


高宝昌a,b,*(), 石雨b, 田媛b, 张治国b, 张婧如b, 孙宇峰b, 毛国梁a, 戴凌燕c,*()   

  1. a 东北石油大学化学化工学院 黑龙江大庆 163319
    b 黑龙江省科学院大庆分院植物化学研究所 黑龙江大庆 163319
    c 黑龙江八一农垦大学生命科学技术学院 黑龙江大庆 163319
  • 收稿日期:2023-08-12 修回日期:2023-10-13 发布日期:2023-11-07
  • 基金资助:
    黑龙江省自然科学基金(LH2020B022); 黑龙江省科学院院长基金(YZ2022DQ01); 黑龙江省科学院双提雁阵特别计划基金(YZQY2023DQ01); 黑龙江省省属科研院所科研业务费基金(YS2023DQ02)

Synthesis of 4-Methyl-2-oxo-6-arylamino-2H-pyran-3-carbonitrile Derivatives

Baochang Gaoa,b(), Yu Shib, Yuan Tianb, Zhiguo Zhangb, Jingru Zhangb, Yufeng Sunb, Guoliang Maoa, Lingyan Daic()   

  1. a College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing, Heilongjiang 163319
    b Institute of Phytochemistry, Daqing Branch of Heilongjiang Academy of Sciences, Daqing, Heilongjiang 163319
    c College of Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319
  • Received:2023-08-12 Revised:2023-10-13 Published:2023-11-07
  • Contact: E-mail:;
  • Supported by:
    Heilongjiang Provincial Natural Science Foundation(LH2020B022); Dean Foundation of Heilongjiang Academy of Sciences(YZ2022DQ01); Shuangtiyanzhen Special Plan Foundation of Heilongjiang Academy of Sciences(YZQY2023DQ01); Institutes Scientific Research Foundation of Heilongjiang Provincial Scientific Research(YS2023DQ02)

2-Pyrone derivatives have demonstrated considerable potential for usage in the field of medicine. Many of these skeleton structures have been used as precursors in the synthesis of pharmacologically active molecules. As a result, it is critical to explore new approaches for the synthesis of 2-pyrones. A series of 2-pyrone derivatives were synthesized from β-oxo amides and ethyl cyanoacetate through one-step reaction. The methodology offers several significant advantages including mild conditions, ease of handling, and high yields (82%~93%). Such, an efficient synthesis approach for 2-pyrones is provided.

Key words: 2-pyrones, β-oxo amides, cyclization