Reductive Amination Reaction of Acetophenone Catalyzed by Ruthenium Complex

doi:10.6023/cjoc201304030

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (11): 2412-2416.DOI: 10.6023/cjoc201304030 Previous Articles Next Articles

Notes

钌络合物催化苯乙酮还原胺化反应的研究

聂红芬, 周宏勇, 李小娜, 李云庆, 王家喜

河北工业大学化工学院天津 300130

收稿日期:2013-04-19 修回日期:2013-07-04 发布日期:2013-07-19
通讯作者: 王家喜 E-mail:wjx.jiaxiwang@gmail.com
基金资助:
河北省自然科学基金（No. B2011202087）资助项目

Reductive Amination Reaction of Acetophenone Catalyzed by Ruthenium Complex

Nie Hongfen, Zhou Hongyong, Li Xiaona, Li Yunqing, Wang Jiaxi

School of Chemical Engineering, Hebei University of Technology, Tianjin 300130

Received:2013-04-19 Revised:2013-07-04 Published:2013-07-19
Supported by:
Project supported by the Natural Science Foundation of Hebei Provice (No. B2011202087).

The catalysts generated in situ from RuCl₂(PPh₃)₃ and α-amino substituted benzimidazole derivatives L₁～L₄ were used to promote the reductive amination of acetophenone to generate α-phenylethylamine, N-(1-phenylethyl) formamide and α-phenylethanol. The bulkier substituent and phenyl group on the ligand will enhance the catalytic activity. The reductive amination of acetophenone was faster at 85 ℃, while the hydrogen transfer of acetophenone to α-phenylethanol became the main reaction at 125 ℃. The hydrogen and amine resouce is the ammonium formate. The plausible mechnism was proposed.

Key words: reductive amination, acetophenone, ammonium formate, ruthenium

Cite this article

Nie Hongfen, Zhou Hongyong, Li Xiaona, Li Yunqing, Wang Jiaxi. Reductive Amination Reaction of Acetophenone Catalyzed by Ruthenium Complex[J]. Chin. J. Org. Chem., 2013, 33(11): 2412-2416.

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钌络合物催化苯乙酮还原胺化反应的研究

Reductive Amination Reaction of Acetophenone Catalyzed by Ruthenium Complex

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