Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

doi:10.6023/cjoc201412009

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 655-661.DOI: 10.6023/cjoc201412009 Previous Articles Next Articles

ARTICLE

金催化分子间氧化炔酰胺合成α-氨基酰胺

李龙, 周波, 叶龙武

固体表面物理化学国家重点实验室福建省化学生物学重点实验室厦门大学化学化工学院厦门 361005

收稿日期:2014-12-03 修回日期:2014-01-01 发布日期:2014-01-09
通讯作者: 叶龙武 E-mail:longwuye@xmu.edu.cn
基金资助:
国家自然科学基金(Nos. 21102119, 21272191)和教育部创新团队资助项目.

Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

Li Long, Zhou Bo, Ye Longwu

State Key Laboratory for Physical Chemistry of Solid Surfaces & The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Received:2014-12-03 Revised:2014-01-01 Published:2014-01-09
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21102119, 21272191) and the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).

1. Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides.PDF(660KB)

Abstract

α-Amino amides constitute an important category of carbonyl compounds which exist in a large number of bioactive natural and non natural molecules. In this paper, an efficient intermolecular reaction of gold carbene intermediates, generated through gold-catalyzed intermolecular oxidation of alkynes, with primary anilines has been realized in aqueous media. Importantly, this non-diazo approach provides a general and practical solution for the synthesis of various functionalized α-amino amides.

Key words: gold catalysis, α-amino amides, gold carbenoids, oxidation

Cite this article

Li Long, Zhou Bo, Ye Longwu. Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides[J]. Chin. J. Org. Chem., 2015, 35(3): 655-661.

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金催化分子间氧化炔酰胺合成α-氨基酰胺

Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

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