Study on the α-Acetoxylation of sp3-C-H Bonds Adjacent to Carbonyl of Arones

doi:10.6023/cjoc201510011

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (4): 826-829.DOI: 10.6023/cjoc201510011 Previous Articles Next Articles

ARTICLE

芳酮类化合物羰基邻位sp³-C-H键的乙酰氧基化反应研究

陈翠, 邱会华

广东石油化工学院化学工程学院茂名 525000

收稿日期:2015-10-12 修回日期:2015-11-21 发布日期:2015-12-10
通讯作者: 陈翠 E-mail:cc161002@gdupt.edu.cn
基金资助:
广东省优秀青年基金(No.2013LYM_0059)资助项目.

Study on the α-Acetoxylation of sp³-C-H Bonds Adjacent to Carbonyl of Arones

Chen Cui, Qiu Huihua

College of Chemcal Engineering, Guangdong University of Petrochemical Technology, Maoming 525000

Received:2015-10-12 Revised:2015-11-21 Published:2015-12-10
Supported by:
Project supported by the Outstanding Youth Fund of Guangdong Province (No. 2013LYM_0059).

1. Study on the α-Acetoxylation of sp³-C-H Bonds Adjacent to Carbonyl of Arones.PDF(3180KB)

Abstract

In this work, an efficient α-acetoxylation of sp³-C-H bonds adjacent to carbonyl of arones to construct α-acetoxy acetophenone derivatives was developed. The influences of reaction time, copper salts, iodine and the loading of copper salts and iodine on this transformation were investigated, and the optimal reaction conditions were also obtained. In addition, a possible reaction mechanism was proposed. This protocol with its advantages of simple procedure and high yield provides a novel valuable approach to α-acetoxy acetophenones.

Key words: acetophenone, sp³-C-H bond, acetoxylation, α-acetoxy acetophenone

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Chen Cui, Qiu Huihua. Study on the α-Acetoxylation of sp³-C-H Bonds Adjacent to Carbonyl of Arones[J]. Chin. J. Org. Chem., 2016, 36(4): 826-829.

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芳酮类化合物羰基邻位sp³-C-H键的乙酰氧基化反应研究

Study on the α-Acetoxylation of sp³-C-H Bonds Adjacent to Carbonyl of Arones

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芳酮类化合物羰基邻位sp3-C-H键的乙酰氧基化反应研究