Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 889-912.DOI: 10.6023/cjoc201511017 Previous Articles     Next Articles



王亮a, 李站a, 万康a, 瞿星a, 胡思前a, 王锋b   

  1. a. 江汉大学光电化学材料与器件教育部重点实验室 化学与环境工程学院 武汉 430056;
    b. 湖北工程学院化学与材料科学学院 孝感 432000
  • 收稿日期:2015-11-06 修回日期:2016-01-10 发布日期:2016-02-01
  • 通讯作者: 胡思前, 王锋;
  • 基金资助:


Progress in Diazo Compounds Mediated Transition-Metal-Catalyzed C—H Alkylation

Wang Lianga, Li Zhanaa, Wan Kanga, Qu Xingaa, Hu Siqiana, Wang Fengb   

  1. a. Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056;
    b. College of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000
  • Received:2015-11-06 Revised:2016-01-10 Published:2016-02-01
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302064) and the Scientific Research Project of Hubei Provincial Department of Education (No. B2015231).

Diazo compounds had been widely employed as a class of environment friendly and highly efficient coupling reagents in transition-metal-catalyzed C—H bonds insertion reactions. Recently, C—H alkylation of various arenes and heteroarenes has been achieved enormous successes using diazo compounds as the alkylation reagents under a new catalytic model. The recent progress in diazo compounds mediated transition-metal-catalyzed C—H alkylation and tandem C—H alkylation/cyclization is reviewed, including reaction mechanism and synthetic applications. Furthermore, the prospects of this reaction are also discussed.

Key words: diazo compounds, transition-metal-catalysis, C—H activation, alkyaltion