Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

doi:10.6023/cjoc201702003

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2044-2049.DOI: 10.6023/cjoc201702003 Previous Articles Next Articles

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新型吡唑酰基脲类化合物的设计合成、杀菌活性与分子对接研究

孙娜波^a, 沈钟华^b, 翟志文^b, 武宏科^b, 翁建全^b, 谭成侠^b, 刘幸海^b

a 浙江树人大学生物与环境学院杭州 310015;
b 浙江工业大学化学工程学院杭州 310014

收稿日期:2017-02-03 修回日期:2017-03-30 发布日期:2017-04-18
通讯作者: 刘幸海 E-mail:xhliu@zjut.edu.cn
基金资助:
国家自然科学基金（No.31401691）和浙江省自然科学基金（No.LY16C14007）资助项目.

Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

Sun Nabo^a, Shen Zhonghu^b, Zhai Zhiwen^b, Wu Hongke^b, Weng Jianquan^b, Tan Chengxia^b, Liu Xinghai^b

a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015;
b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received:2017-02-03 Revised:2017-03-30 Published:2017-04-18
Contact: 10.6023/cjoc201702003 E-mail:xhliu@zjut.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 31401691) and the Zhejiang Provincial Natural Science Foundation of China (No. LY16C14007).

1. Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety.PDF(1368KB)

Abstract

A series of novel acyl urea derivatives containing pyrazole moiety were synthesized from ethyl acetoacetate, triethyl orthoformate, methylhydrazine by multi-step reactions. Their structures were characterized by ¹H NMR and HRMS spectra. The target compounds were evaluated for their fungicidal activity. The results indicated that some of the title compounds displayed certain fungicidal activities against Cercospora arachidicola, Sclerotinia sclerotiorum, Rhizoctonia solani and Physalopora piricola. The docking results indicated the hydrogen bond formed between the amide group and Ser 39 residue.

Key words: pyrazole, acyl urea, synthesis, fungicidal activity, docking

Cite this article

Sun Nabo, Shen Zhonghu, Zhai Zhiwen, Wu Hongke, Weng Jianquan, Tan Chengxia, Liu Xinghai. Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety[J]. Chin. J. Org. Chem., 2017, 37(8): 2044-2049.

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新型吡唑酰基脲类化合物的设计合成、杀菌活性与分子对接研究

Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

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