Progress of Organic Reactions Catalyzed by N-Heterocyclic Carbenes

doi:10.6023/cjoc201702041

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2590-2608.DOI: 10.6023/cjoc201702041 Previous Articles Next Articles

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氮杂环卡宾催化有机反应的研究进展

王翱^a,b, 肖永龙^b, 周宇^b, 徐进宜^a, 柳红^b

a 中国药科大学天然药物活性物质与功能国家重点实验室南京 210000;
b 中国科学院上海药物研究所受体结构与功能重点实验室上海 201203

收稿日期:2017-02-26 修回日期:2017-05-25 发布日期:2017-06-02
通讯作者: 周宇, 柳红 E-mail:zhouyu@simm.ac.cn;hliu@simm.ac.cn
基金资助:
国家自然科学基金（No.21632008）资助项目.

Progress of Organic Reactions Catalyzed by N-Heterocyclic Carbenes

Wang Ao^a,b, Xiao Yonglong^b, Zhou Yu^b, Xu Jinyi^a, Liu Hong^b

a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000;
b CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received:2017-02-26 Revised:2017-05-25 Published:2017-06-02
Contact: 10.6023/cjoc201702041 E-mail:zhouyu@simm.ac.cn;hliu@simm.ac.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No.21632008).

Since the first stable N-heterocyclic carbene was isolated by Arduengo in 1991, N-heterocyclic carbine has developed rapidly as a kind of efficient organic catalyst. It plays important role in building complex molecules in organic synthesis for the characteristics of umpolung. Some special Lewis bases and oxidants can induce carbine reaction with carbonyl to form Breslow intermediates, enol and homoenolate, which expand the reaction greatly. In this paper, the recent progresses in organic catalytic reactions including Stetter reaction, a³-d³ umpolung catalyzed by carbines are reviewed.

Key words: N-heterocyclic carbene, organic catalytic, umpolung

Cite this article

Wang Ao, Xiao Yonglong, Zhou Yu, Xu Jinyi, Liu Hong. Progress of Organic Reactions Catalyzed by N-Heterocyclic Carbenes[J]. Chin. J. Org. Chem., 2017, 37(10): 2590-2608.

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氮杂环卡宾催化有机反应的研究进展

Progress of Organic Reactions Catalyzed by N-Heterocyclic Carbenes

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