Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3177-3185.DOI: 10.6023/cjoc201704036 Previous Articles     Next Articles



杨权力a, 宋玉叶a, 余平a, 王龙b, 刘明国a, 黄年玉a   

  1. a 三峡大学生物与制药学院 天然产物研究与利用湖北省重点实验室 宜昌 443002;
    b 三峡大学材料与化工学院 宜昌 443002
  • 收稿日期:2017-04-21 修回日期:2017-08-10 发布日期:2017-09-08
  • 通讯作者: 黄年玉
  • 基金资助:


1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-Promoted Stere-oselective Synthesis of Oxazolidin-2-(thi)one Derivatives

Yang Quanlia, Song Yuyea, Yu Pinga, Wang Longb, Liu Mingguoa, Huang Nianyua   

  1. a Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002;
    b College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002
  • Received:2017-04-21 Revised:2017-08-10 Published:2017-09-08
  • Contact: 10.6023/cjoc201704036
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21602123), the Youth Talent Development Foundation and Scientific Foundation from Graduate School of China Three Gorges University (No. SDYC2016121).

A series of multi-substituted oxazolidin-2-(thi)one derivatives were prepared via 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) promoted nucleophilic addition/cyclization from alkynyl alcohol and isocynate or thiocynate in high yields of 75%~95%. This concise and efficient approach provides a facial access to a library of biological (Z)-arylmethylene substituted oxazolidin-2-(thi)one derivatives with high stereo-selectivities.

Key words: oxazolidin-2-(thi)one, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), stereo-selectivity