A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

doi:10.6023/cjoc201804028

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 3137-3140.DOI: 10.6023/cjoc201804028 Previous Articles Next Articles

Notes

异叶三宝木枝叶中一个新的Stemodane型二萜类化合物

刘艳萍^a,b, 张项林^a,b, 牛海渊^a,b, 官春艳^a,b, 孙福康^a,b, 杨柳萌^c, 付艳辉^a,b

a 海南师范大学热带药用植物化学教育部重点实验室海口 571158;
b 海南师范大学南药资源产业化关键技术研究海口市重点实验室海口 571158;
c 中国科学院昆明动物研究所中国科学院动物模型与人类疾病机理重点实验室昆明 650223

收稿日期:2018-04-15 修回日期:2018-06-03 发布日期:2018-06-29
通讯作者: 付艳辉 E-mail:fuyanhui80@163.com
基金资助:
海南省重点研发计划（No.ZDYF2016221）、海口市重点研发计划（No.2017050）、国家自然科学基金（Nos.21662011，31660097）和教育部创新发展团队项目（No.IRT-16R19）资助项目.

A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

Liu Yanping^a,b, Zhang Xianglin^a,b, Niu Haiyuan^a,b, Guan Chunyan^a,b, Sun Fukang^a,b, Yang Liumeng^c, Fu Yanhui^a,b

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158;
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158;
c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223

Received:2018-04-15 Revised:2018-06-03 Published:2018-06-29
Supported by:
Project supported by the Key Research and Development Project of Hainan Province (No. ZDYF2016221), the Key Research and Development Project of Haikou City (No. 2017050), the National Natural Science Foundation of China (Nos. 21662011, 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19).

1. A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus.PDF(671KB)

Abstract

A new stemodane diterpenoid, trigoheterone A (1), together with seven known diterpenoids, was isolated from the stems and leaves of Trigonostemon heterophyllus. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The cytotoxicities of all isolated compounds were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). As a result, eight compounds exhibited significant inhibitory effects with IC₅₀ values comparable to those of cisplatin.

Key words: Trigonostemon, Trigonostemon heterophyllus, stemodane diterpenoid, cytotoxicities

Cite this article

Liu Yanping, Zhang Xianglin, Niu Haiyuan, Guan Chunyan, Sun Fukang, Yang Liumeng, Fu Yanhui. A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus[J]. Chin. J. Org. Chem., 2018, 38(11): 3137-3140.

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异叶三宝木枝叶中一个新的Stemodane型二萜类化合物

A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

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