I2-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles

doi:10.6023/cjoc201806026

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3236-3241.DOI: 10.6023/cjoc201806026 Previous Articles Next Articles

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碘介导下通过氧化性C-O键形成合成异噁唑类化合物

侯姣, 张新婷, 于文全, 常俊标

郑州大学化学与分子工程学院郑州 450001

收稿日期:2018-06-16 修回日期:2018-08-02 发布日期:2018-08-23
通讯作者: 于文全, 常俊标 E-mail:wenquan_yu@zzu.edu.cn;changjunbiao@zzu.edu.cn
基金资助:
国家自然科学基金（Nos.81773570，81330075）和郑州大学优秀青年人才研究基金（No.1521316004）资助项目.

I₂-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles

Hou Jiao, Zhang Xinting, Yu Wenquan, Chang Junbiao

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001

Received:2018-06-16 Revised:2018-08-02 Published:2018-08-23
Contact: 10.6023/cjoc201806026 E-mail:wenquan_yu@zzu.edu.cn;changjunbiao@zzu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81773570, 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004).

1. I₂-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles.PDF(2967KB)

Abstract

A variety of mono-, di-, and tri-substituted (aryl, alkyl, and/or alkenyl) isoxazoles were synthesized from readily accessible α,β-unsaturated oximes via I₂-mediated oxidative C-O bond formation. The features of this synthetic approach include no use of transition metals, simple operation, mild reaction conditions, short reaction time, and broad substrate scope.

Key words: isoxazole, iodine, α,β-unsaturated oxime, C-O bond formation

Cite this article

Hou Jiao, Zhang Xinting, Yu Wenquan, Chang Junbiao. I₂-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles[J]. Chin. J. Org. Chem., 2018, 38(12): 3236-3241.

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碘介导下通过氧化性C-O键形成合成异噁唑类化合物

I₂-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles

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