Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols

doi:10.6023/cjoc201806039

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3242-3249.DOI: 10.6023/cjoc201806039 Previous Articles Next Articles

Articles

钌(Ⅱ)-催化芳胺C-H键与炔丙醇的高选择性[3+2]环化反应

白丽丽, 王颖, 王烁今, 孔杜林, 付艳, 彭德乾, 文丽君, 陈训

海南医学院药学院海口 571199

收稿日期:2018-06-25 修回日期:2018-07-23 发布日期:2018-08-23
通讯作者: 彭德乾, 陈训 E-mail:pengdeqian2004@163.com;chenxunchenpei@163.com
基金资助:
海南省科协青年科技英才学术创新计划（Nos.QCXM201808，QCXM201707）资助项目.

Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols

Bai Lili, Wang Ying, Wang Shuojin, Kong Dulin, Fu Yan, Peng Deqian, Wen Lijun, Chen Xun

School of Pharmacy, Hainan Medical University, Haikou 571199

Received:2018-06-25 Revised:2018-07-23 Published:2018-08-23
Contact: 10.6023/cjoc201806039 E-mail:pengdeqian2004@163.com;chenxunchenpei@163.com
Supported by:
Project supported by the Program of Hainan Association for Science and Technology Plans to Youth R & D Innovation (Nos. QCXM201808, QCXM201707).

1. Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols.PDF(3246KB)

Abstract

A simple and efficient ruthenium(Ⅱ)-catalyzed C-H bond regioselective[3+2] annulation of arylamines with propargyl alcohols has been reported. This protocol provides a facile approach to hydroxy-containing indole skeleton, which could be employed for constructing more complex and useful pharmaceutical molecules. Meantime, the kinetic isotope effect was further investigated and the results indicated that the C-H bond-breaking was possibly involved in the rate-limiting step of this transformation.

Key words: ruthenium(Ⅱ), C-H bond, regioselective, annulation reaction

Cite this article

Bai Lili, Wang Ying, Wang Shuojin, Kong Dulin, Fu Yan, Peng Deqian, Wen Lijun, Chen Xun. Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols[J]. Chin. J. Org. Chem., 2018, 38(12): 3242-3249.

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钌(Ⅱ)-催化芳胺C-H键与炔丙醇的高选择性[3+2]环化反应

Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols

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