Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1188-1205.DOI: 10.6023/cjoc201910002 Previous Articles     Next Articles


欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺   

  1. 南昌师范学院 南昌 330032
  • 收稿日期:2019-10-05 修回日期:2019-12-16 发布日期:2012-06-19
  • 通讯作者: 欧阳班来
  • 基金资助:

Recent Progress in Transition Metal Catalyzed Sulfonamidation of Aromatic Compounds

Ouyang Banlai, Zheng Yanxia, Xia Kejian, Xu Xiaoling, Wang Yi   

  1. Department of Chemistry, Nanchang Normal University, Nanchang 330032
  • Received:2019-10-05 Revised:2019-12-16 Published:2012-06-19
  • Supported by:
    Project supported by the Open Project Program of Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University (No. KLFS-KF-201721) and the Science and Technology Project of the Education Department of Jiangxi Province (No. GJJ161235).

The N-arylsulfonamide group is an important moiety in medicinal chemistry because of its presence in many useful molecules with potential bioactivities. As a result, the development of synthetic routes to N-arylsulfonamides has been actively investigated. In recent years, the transition metal-catalyzed sulfonamidations of aryl halides, arylboronic acids and CAr-H bonds have extensively investigated, providing more efficient and environmentally friendly procedures for the synthesis of N-arylsulfonamides. The recent progress in the transition metal-catalyzed sulfonamidation reactions is reviewed. The aromatic substrates, transition metal-catalysts, ligands, sulfonamidating reagents, mechanisms of the sulfonamidation reactions are mainly discussed. Finally, the future development of them is also prospected.

Key words: N-arylsulfonamides, sulfonamidation, transition metal-catalyzed, C-N bond construction, C-H bond activation