Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200

doi:10.6023/cjoc201808023

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 538-543.DOI: 10.6023/cjoc201808023 Previous Articles Next Articles

Notes

聚乙二醇200溶剂中镍催化合成喹唑啉酮衍生物

许贻文, 张鹏, 刘彩琴, 林晨, 林小燕, 柯方

福建医科大学药学院福州 350004

收稿日期:2018-08-20 修回日期:2018-09-10 发布日期:2018-09-26
通讯作者: 柯方 E-mail:kefang@163.com
基金资助:
福建省自然科学基金（Nos.2016J01686，2016J01372，2016Y9051，2017J01820）和福建医科大学基金（No.2015MP008）资助项目.

Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200

Xu Yiwen, Zhang Peng, Liu Caiqin, Lin Chen, Lin Xiaoyan, Ke Fang

Department of Pharmacy, Fujian Medical University, Fuzhou 350004

Received:2018-08-20 Revised:2018-09-10 Published:2018-09-26
Contact: 10.6023/cjoc201808023 E-mail:kefang@163.com
Supported by:
Project supported by the Natural Science Foundation of Fujian Province (Nos. 2016J01686, 2016J01372, 2016Y9051, 2017J01820) and the Research Fund of Fujian Medical University (No. 2015MP008).

1. Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200.PDF(1498KB)

Abstract

A simple and economic method for synthesizing quinazolinones from substituted 2-halobenzoic acids and amidines was developed by nickel-catalysis in wet polyethylene glycol 200 (PEG 200) as an eco-friendly medium. The present methodology is operationally simple, non-toxic and non-irritative, and varieties of quinazolinone derivatives were obtained in high yields of up to 94%.

Key words: polyethylene glycol 200 (PEG 200), quinazolinone, nickel chloride, 2-halobenzoic acid, amidine

Cite this article

Xu Yiwen, Zhang Peng, Liu Caiqin, Lin Chen, Lin Xiaoyan, Ke Fang. Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200[J]. Chin. J. Org. Chem., 2019, 39(2): 538-543.

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聚乙二醇200溶剂中镍催化合成喹唑啉酮衍生物

Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200

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