Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (3): 847-853.DOI: 10.6023/cjoc202110002 Previous Articles     Next Articles



李玉东a,b, 李莹a, 董亚楠a, 夏春谷a,*(), 李跃辉a,*()   

  1. a 中国科学院兰州化学物理研究所苏州研究院 羰基合成与选择氧化国家重点实验室 兰州 730000
    b 中国科学院大学 北京 100049
  • 收稿日期:2021-10-02 修回日期:2021-10-30 发布日期:2021-11-09
  • 通讯作者: 夏春谷, 李跃辉
  • 基金资助:
    国家自然科学基金(22022204); 国家自然科学基金(21633013); 国家自然科学基金(22072167)

Manganese-Catalyzed Allylation of Quinazolinones with 4-Vinyl-1,3-dioxolan-2-one via C—H Activation

Yudong Lia,b, Ying Lia, Ya'nan Donga, Chungu Xiaa(), Yuehui Lia()   

  1. a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000
    b University of Chinese Academy of Sciences, Beijing 100049
  • Received:2021-10-02 Revised:2021-10-30 Published:2021-11-09
  • Contact: Chungu Xia, Yuehui Li
  • Supported by:
    National Natural Science Foundation of China(22022204); National Natural Science Foundation of China(21633013); National Natural Science Foundation of China(22072167)

The ortho-allylation of quinazolinones with 4-vinyl-1,3-dioxolan-2-one via manganese catalysis has been described. A series of allylation products with potential applications have been obtained. This protocol is also highlighted by good compatibility of functional groups and excellent E/Z selectivity. This work broadens the scope of Mn-catalyzed C—C coupling reactions.

Key words: manganese-catalyzed, allylation, quinazolinones, C—H activation