Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1304-1315.DOI: 10.6023/cjoc201809034 Previous Articles     Next Articles



赵鑫雨a, 丁扬扬a, 吕英涛b, 康从民a   

  1. a 青岛科技大学化工学院 青岛 266042;
    b 青岛科技大学海洋学院 青岛 266042
  • 收稿日期:2018-09-27 修回日期:2018-11-24 发布日期:2019-01-10
  • 通讯作者: 康从民
  • 基金资助:


Research Progress on Green Synthesis of Imidazo[1,2-a]pyridine Compounds

Zhao Xinyua, Ding Yangyanga, Lü Yingtaob, Kang Congmina   

  1. a College of Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao 266042;
    b Ocean College, Qingdao University of Science and Technology, Shandong Province, Qingdao 266042
  • Received:2018-09-27 Revised:2018-11-24 Published:2019-01-10
  • Contact: 10.6023/cjoc201809034
  • Supported by:

    Project supported by the Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique (No. MBSMAT-2017-06).

Imidazo[1,2-a]pyridine compounds were 5- and 6-membered nitrogen heterocyclic compounds, which were found in various natural products and exhibited a wide range of pharmacological activities, and were widely used in medical chemistry. Imidazo[1,2-a]pyridines have important research significance and broad medical application prospects, so the synthetic strategy literatures on the diversity of such compounds have been continuously reported. In recent years, green chemistry was one of the hot trends in contemporary chemistry. More and more attention is paid to green synthesis and constantly developing various green synthesis solutions. Among them, one-pot "multi-component" reaction, microwave reaction and solid phase synthesis, which were green and high-efficiency synthetic methods, have been the focus of research. From the three types of green synthesis methods, The research progress of imidazole[1,2-a]pyridine green synthesis in recent years is summarized.

Key words: green synthesis, one pot "multi-component reaction", microwave reaction, solid phase synthesis