Progress of N-Benzyl Removal

doi:10.6023/cjoc201901031

Abstract

N-Benzyl is a common protecting group for organic amines, owing to its convenient and efficient removal. It plays an important role in organic synthesis, especially in the research of drugs and natural products. In recent years, a large number of researchers have conducted extensive studies on N-benzyl deprotection, but the related work is scattered and lacks systematic review. Therefore, the progress of N-benzyl removal is systematically and comprehensively summarized from the aspects of reductive, oxidative and acid-base debenzylation.

Key words: organic amine, N-benzyl protection, reductive debenzylation, oxidative debenzylation, acid-base debenzylation

Cite this article

Zhou Guangwei, Zhang Lizhu, Xue Yahan, Li Jiarong. Progress of N-Benzyl Removal[J]. Chin. J. Org. Chem., 2019, 39(9): 2428-2442.

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