Computational Studies on Reaction Mechanism of the Catalyst-Controlled Selective Insertion of Metal Carbenoids into C-C and C-H Bonds of 1,3-Dicarbonyl Compounds

doi:10.6023/cjoc202003003

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2468-2475.DOI: 10.6023/cjoc202003003 Previous Articles Next Articles

催化剂调控的金属卡宾与1,3-二羰基化合物选择性C—C键与C—H键插入反应机理的理论研究

曹姗姗, 刘兆洪, 袁海艳, 杨柳, 张景萍, 毕锡和

东北师范大学化学学院长春 130024

收稿日期:2020-03-02 修回日期:2020-05-13 发布日期:2020-05-20
通讯作者: 刘兆洪, 张景萍, 毕锡和 E-mail:liuzh944@nenu.edu.cn;zhangjp162@nenu.edu.cn;bixh507@nenu.edu.cn
基金资助:
国家自然科学基金（Nos.21871043，21961130376）资助项目.

Computational Studies on Reaction Mechanism of the Catalyst-Controlled Selective Insertion of Metal Carbenoids into C-C and C-H Bonds of 1,3-Dicarbonyl Compounds

Cao Shanshan, Liu Zhaohong, Yuan Haiyan, Yang Liu, Zhang Jingping, Bi Xihe

School of Chemistry, Northeast Normal University, Changchun 130024

Received:2020-03-02 Revised:2020-05-13 Published:2020-05-20
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21871043, 21961130376).

1. cjoc202003003辅助材料.pdf(2088KB)

Abstract

Density functional theory (DFT) calculations were carried out to investigate the mechanism and chemoselectivity of silver-or scandium-catalyzed insertion of diazo compounds into C-C or C-H bonds of 1,3-dicarbonyl compounds. The results show that silver and scandium carbenes are readily generated by metal-induced extrusion of nitrogen from diazo compounds. When low-coordinated silver(I) is used as the catalyst, carbene insertion into the C-C bond of 1,3-dicarbonyls leads to 1,4-dicarbonyl product containing an all-carbon α-quaternary center, through a cascade sequence of electrophilic addition, intramolecular cyclization, selective ring-opening and enol isomerization. When highly coordinated scandium(III) is used, carbene insertion into C-H bond of 1,3-dicarbonyls leads to 1,3-dicarbonyl product containing α-tertiary center, through a cascade sequence of electrophilic addition and protonation. Computational studies show that the chemoselectivity results from the cooperative effect of ring tension and the difference in coordination number of metal centers, which provides useful insight into the development of transition metal-catalyzed carbene transfer reactions.

Key words: density functional theory, silver carbenoid, scandium carbenoid, chemoselectivity

Cite this article

Cao Shanshan, Liu Zhaohong, Yuan Haiyan, Yang Liu, Zhang Jingping, Bi Xihe. Computational Studies on Reaction Mechanism of the Catalyst-Controlled Selective Insertion of Metal Carbenoids into C-C and C-H Bonds of 1,3-Dicarbonyl Compounds[J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2468-2475.

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催化剂调控的金属卡宾与1,3-二羰基化合物选择性C—C键与C—H键插入反应机理的理论研究

Computational Studies on Reaction Mechanism of the Catalyst-Controlled Selective Insertion of Metal Carbenoids into C-C and C-H Bonds of 1,3-Dicarbonyl Compounds

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