Recent Progress in Monofluoromethylation

doi:10.6023/cjoc202003055

Abstract

Organic fluorides play an indispensable role in medicine, agricultural chemistry and other fields, among them fluoromethyl functional groups have strong lipophilicity, which can greatly improve the pharmacokinetics properties of drug molecules. Therefore, it is of great value to develop various fluorination reactions, especially to introduce monofluoromethyl into molecules in fluorination chemistry. The research progress of the monofluoromethylation of different structural molecules is summarized according to the classification of fluoromethyl reagents, and the possible mechanism of some reactions is discussed.

Key words: organic fluoride, fluoromethyl functional group, fluoromethyl reagent, monofluoromethylation reaction

Cite this article

Liu Yingjie, Li Chen, Meng Jianping, Song Dongxue, Liu Bing, Xu Ying. Recent Progress in Monofluoromethylation[J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2322-2337.

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