Synthesis and Properties of Blood Compatible Polyurethane Elastomer

doi:10.6023/cjoc202006004

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4344-4349.DOI: 10.6023/cjoc202006004 Previous Articles Next Articles

血液相容性聚氨酯弹性体的合成与性能研究

鞠明杰^a, 徐彬彬^b, 徐立功^a

a 华东理工大学体育科学与工程学院上海 200237;
b 华东理工大学材料科学与工程学院上海 200237

收稿日期:2020-06-04 修回日期:2020-06-16 发布日期:2020-08-06
通讯作者: 徐彬彬, 徐立功 E-mail:binbinxu@ecust.edu.cn;xuligong@ecust.edu.cn
基金资助:
国家自然科学基金（No.22001072）和上海市青年科技英才扬帆计划（No.19YF1410300）资助项目.

Synthesis and Properties of Blood Compatible Polyurethane Elastomer

Ju Mingjie^a, Xu Binbin^b, Xu Ligong^a

a School of Sports Science and Engineering, East China University of Science and Technology, Shanghai 200237;
b School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237

Received:2020-06-04 Revised:2020-06-16 Published:2020-08-06
Supported by:
Project supported by National Natural Science Foundation of China (No. 22001072), and Shanghai Sailing Program (No. 19YF1410300)

1. cjoc202006004.pdf(873KB)

Abstract

Polyurethane materials are widely used in biomedical fields such as implantable catheters and drug delivery. However, their blood compatibility is difficult to meet the rigorous requirements needed for a new generation of biomedical devices. A series of polyurethane elastomers were prepared using polycarbonate diols (PC), polyoxytertramethylene glycol (PTMG), isophorone diisocyanate (IPDI) and chain extender (BDO, E-300) as raw materials. The properties of polyurethane elastomers were investigated by FT-IR spectrum, differential scanning calorimeter (DSC) analysis, mechanical test, water contact angle measurement, hemolysis and cell compatibility test. The mechanical results show that the materials have superior tensile strength and elongation, meanwhile, the homolysis and cells compatibility tests exhibit that they have good bio-compatibility. In addition, the materials can achieve the best performance by using IPDI as well as chain extender E-300 as the hard segment and PC as the soft segment.

Key words: polyurethane, elastomer, hemolysis, blood compatibility

Cite this article

Ju Mingjie, Xu Binbin, Xu Ligong. Synthesis and Properties of Blood Compatible Polyurethane Elastomer[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4344-4349.

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血液相容性聚氨酯弹性体的合成与性能研究

Synthesis and Properties of Blood Compatible Polyurethane Elastomer

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