Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (7): 2910-2913.DOI: 10.6023/cjoc202101006 Previous Articles     Next Articles

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诺丽酵素中两个新的酚类衍生物及其α-葡萄糖苷酶抑制活性

张斌a,b, 周学明a,b, 余章昕a,b,c, 李小宝a,b, 易继凌a,b, 黄柯蕾a,b, 唐春美a,b, 刘晴a,b, 陈光英a,b,*()   

  1. a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158
    c 海南医学院 热带转化医学教育部重点实验室 海口 571199
  • 收稿日期:2021-01-04 修回日期:2021-03-18 发布日期:2021-04-06
  • 通讯作者: 陈光英
  • 基金资助:
    海南省重点研发项目(ZDYF2019165); 教育部创新研究团队项目(IRT-16R19); 国家自然科学基金(21662012); 国家自然科学基金(4186605); 海南医学院热带转化医学教育部重点实验室的开放基金(2020TTM001); 海南省研究生创新研究(Hyb2020-54)

Two New Phenolic Derivatives withα-Glucosidase Inhibitory Activities fromNoni Juice

Bin Zhanga,b, Xueming Zhoua,b, Zhang-Xin Yua,b,c, Xiaobao Lia,b, Jiling Yia,b, Kelei Huanga,b, Chunmei Tanga,b, Qing Liua,b, Guangying Chena,b()   

  1. a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    c Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199
  • Received:2021-01-04 Revised:2021-03-18 Published:2021-04-06
  • Contact: Guangying Chen
  • Supported by:
    Key Research and Development Project of Hainan Province(ZDYF2019165); Innovative Research Team Project of Ministry of Education(IRT-16R19); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(4186605); Open Foundation of Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University(2020TTM001); Innovative Research Projects of Postgraduates in Hainan Universities(Hyb2020-54)

Two new lactic acid derivatives of noniacids A and B (1 and 2) and a new natural product melilotic acid (3) were obtained from the ethyl acetate extract of theNoni Juice. The structures were elucidated using comprehensive spectroscopic methods, and the absolute configurations were defined by comparing optical rotation with the standard. Compounds 1 and 2 showed significant inhibitory activity againstα-glucosidase enzyme with IC50 values of 242.0 and 229.3 µmol•L–1, respectively.

Key words: Noni Juice, phenolic derivatives, α-glucosidase activity