Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (7): 2760-2766.DOI: 10.6023/cjoc202101010 Previous Articles     Next Articles

ARTICLES

铜催化的2H-1,2,3-三氮唑的绿色制备

毕晶晶*(), 孙潇潇, 高松, 陈长坡, 张贵生*()   

  1. 河南师范大学化学化工学院 绿色化学介质与反应教育部重点实验室 精细化学品绿色制造协同创新中心 河南省有机功能分子与药物创新重点实验室 河南新乡 453007
  • 收稿日期:2021-01-06 修回日期:2021-03-22 发布日期:2021-04-16
  • 通讯作者: 毕晶晶, 张贵生
  • 基金资助:
    国家自然科学基金(21702051); 河南省博士后科学基金(001802033); 河南省科技攻关(212102311022); 河南师范大学青年科学基金(2016QK10)

Copper Catalyzed Synthesis of 2H-1,2,3-Triazoles in Green Solvent

Jingjing Bi(), Xiaoxiao Sun, Song Gao, Changpo Chen, Guisheng Zhang()   

  1. Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
  • Received:2021-01-06 Revised:2021-03-22 Published:2021-04-16
  • Contact: Jingjing Bi, Guisheng Zhang
  • Supported by:
    National Natural Science Foundation of China(21702051); Postdoctoral Science Foundation of Henan Province(001802033); Henan Science and Technology Program(212102311022); Henan Normal University Science Foundation for Young Scholars(2016QK10)

The hydrolysis of 4-substituted 1-sulfonyl-1,2,3-triazoles induced by a catalytic amount of copper sulfate in the green solvent of H2O/PEG-400 was reported, providing a wide range of 4-substituted-2H-1,2,3-triazoles in excellent yields. The approach provides a green, simple and effective method for the preparation of 2H-1,2,3-triazole compounds. Bromination, arylation, and alkylation on 2H-1,2,3-triazoles by the one-pot method were also explored.

Key words: 2H-1,2,3-triazole, copper sulfate, triazole derivative, green solvent