Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (9): 3585-3592.DOI: 10.6023/cjoc202105010 Previous Articles     Next Articles



傅琴姣, 张瑞芹, 裘浣沂, 马仁超*(), 马永敏*()   

  1. 台州学院医药化工学院 浙江台州 318000
  • 收稿日期:2021-05-07 修回日期:2021-06-07 发布日期:2021-07-12
  • 通讯作者: 马仁超, 马永敏
  • 基金资助:

A New Method for the Synthesis of 2-Arylbenzothiazoles Oxidized by Selectfluor

Qinjiao Fu, Ruiqin Zhang, Huanyi Qiu, Renchao Ma(), Yongmin Ma()   

  1. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000
  • Received:2021-05-07 Revised:2021-06-07 Published:2021-07-12
  • Contact: Renchao Ma, Yongmin Ma
  • Supported by:
    Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01005)

2-Arylbenzothiazoles were effectively synthesized via an oxidative process by Selectfluor in 1-butanol at 120 ℃, using 2-arylbenzothiazoles and aryl/aliphatic ketones as starting materials. Bioactive pharmaceutical intermediates were obtained by selecting substituents on the ring of aryl methyl ketones.

Key words: Selectfluor, 2-arylbenzothiazole, aryl methyl ketone, 2-aminobenzenethiol, oxidation