A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

doi:10.6023/cjoc202112019

Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (7): 2243-2247.DOI: 10.6023/cjoc202112019 Previous Articles Next Articles

NOTE

栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

刘绪, 苏盼杰, 崔文博, 张宗萍, 陈晓涵, 王儒月, 费冬青^*(), 张占欣^*()

兰州大学药学院功能有机分子化学国家重点实验室兰州 730000

收稿日期:2021-12-15 修回日期:2022-03-23 发布日期:2022-08-09
通讯作者: 费冬青, 张占欣
作者简介:
^† 共同第一作者
基金资助:
国家自然科学基金(31670350); 国家自然科学基金(31870324); 甘肃省自然科学基金(21JR7RA444); 甘肃省自然科学基金(21JR7RA477)

A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

Xu Liu, Panjie Su, Wenbo Cui, Zongping Zhang, Xiaohan Chen, Ruyue Wang, Dongqing Fei(), Zhanxin Zhang()

School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000

Received:2021-12-15 Revised:2022-03-23 Published:2022-08-09
Contact: Dongqing Fei, Zhanxin Zhang
About author:
^† These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China(31670350); National Natural Science Foundation of China(31870324); Natural Science Foundation of Gansu Province(21JR7RA444); Natural Science Foundation of Gansu Province(21JR7RA477)

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Abstract

One new germacrane-type sesquiterpene lactone, named as salviatanolide A (1) was isolated from an ethanol extract of the whole plant of Salvia castanea. Its structure was elucidated by 1D and 2D-NMR and HRESIMS spectra, and its absolute configuration was determined by single crystal X-ray crystallography. The anti-Alzheimer’s disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model. Compound 1 significantly delayed AD-like symptoms of worm paralysis phenotype, which may be potential to be served as anti-AD agent candidate.

Key words: Salvia castanea, germacrane-type sesquiterpene lactone, anti-Alzheimer’s disease activity, Caenorhabditis elegans

Cite this article

Xu Liu, Panjie Su, Wenbo Cui, Zongping Zhang, Xiaohan Chen, Ruyue Wang, Dongqing Fei, Zhanxin Zhang. A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea[J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 2243-2247.

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Fig. & Tab. 5

Figure 1. Chemical structure of compound 1

Figure 2. Key 1H-1H COSY and HMBC correlations of 1

Figure 3. Key NOESY correlations of 1

Figure 4. Single-crystal X-ray ORTEP drawing of 1

Figure 5. Anti-Alzheimer’s disease (AD) activity of compound 1, positive control and control Worms were treated with 100 μmol/L compound 1, 100 μmol/L memantine was regarded as positive control, and 0.1% dimethyl sulfoxide (DMSO) was regarded as control

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栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

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Fig. & Tab. 5

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