Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (8): 2864-2877.DOI: 10.6023/cjoc202302017 Previous Articles     Next Articles


王熠a, 张键b, 刘飏子b, 罗晓燕a,*(), 邓卫平a,b,*()   

  1. a 华东理工大学药学院 上海 200237
    b 浙江师范大学化学与材料科学学院 浙江金华 321004
  • 收稿日期:2023-02-25 修回日期:2023-04-04 发布日期:2023-04-25
  • 基金资助:
    国家重点研发计划(2021YFA0804900); 国家自然科学基金(21971062); 国家自然科学基金(22171082); 上海细胞代谢光遗传学技术前沿科学研究基地资助项目

Palladium-Catalyzed Asymmetric [3+4] Cycloadditions for the Construction of Cyclohepta[b]indoles

Yi Wanga, Jian Zhangb, Yangzi Liub, Xiaoyan Luoa(), Weiping Denga,b()   

  1. a School of Pharmacy, East China University of Science and Technology, Shanghai 200237
    b College of Chemistry, Zhejiang Normal University, Jinhua 321004
  • Received:2023-02-25 Revised:2023-04-04 Published:2023-04-25
  • Contact: *E-mail:;
  • Supported by:
    The National Key Research and Development Program of China(2021YFA0804900); The National Natural Science Foundation of China(21971062); The National Natural Science Foundation of China(22171082); The Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism

A Pd-catalyzed decarboxylation strategy for the efficient synthesis of cyclohepta[b]indoles in good yields with good to excellent enantioselectivities and moderate diastereoselectivities is reported. In this procedure, viny indoloxazolidones were activated by Pd catalyst to generate zwitterionic intermediates in situ, which were then trapped by the electro-deficient diene species via the asymmetric [3+4] cycloaddition process.

Key words: decarboxylation, cyclohepta[b]indoles, asymmetric, cycloadditions