Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (3): 855-872.DOI: 10.6023/cjoc202212039 Previous Articles     Next Articles

Special Issue: 中国女科学家专辑



郭萍, 周勇, 赵杰*()   

  1. 华东理工大学化学与分子工程学院 上海 200237
  • 收稿日期:2022-12-03 修回日期:2023-02-25 发布日期:2023-02-28
  • 通讯作者: 赵杰

ZE Selective Preparation of Disubstituted Internal Alkenes and Trisubstituted Alkenes

Ping Guo, Yong Zhou, Jie Zhao()   

  1. School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237
  • Received:2022-12-03 Revised:2023-02-25 Published:2023-02-28
  • Contact: Jie Zhao

Olefin is one of the most important bulk chemicals in industry as well as commonly used starting materials in pharmaceutical field. Since Z-olefins and E-olefins exhibit great differences in physicochemical properties and biological activities, the ZE configuration control has been playing important roles in olefin preparation. The selective synthetic methods of ZE configurations of disubstituted inner alkenes and trisubstituted alkenes are reviewed, including the Wittig reaction, substituted alkane elimination reaction, olefin isomerization reaction, olefin metathesis, olefin coupling reaction, and alkyne addition reaction. The catalyst types and controlling factors of ZE selectivity in these synthetic examples are described in detail.

Key words: disubstituted internal olefins, trisubstituted olefins, ZE selectivity